5 glycosyltransferase activities have been found.
Please note that CSDB GT database covers only a few species: Arabidopsis thaliana, Escherichia coli, Saccharomyces cerevisiae, Acinetobacter baumannii.
| Enzyme / Gene | Activity | Object | References |
|---|---|---|---|
| Enzyme name: gpi14p UniProt ID: P47088* CAZy family: GT50 Gene name: GPI14 Gene GenBank ID: 853470* | Synthesized dimer: aDManp(1-4)aDGlcpN Donor (ID 34645): ?DManp(1-P-1)Subst // Subst = dolichol Acceptor (ID 34886): LIP(1-2)[LIP(1-3),aDGlcpN(1-6)xXmyoIno(1-P-1)]xDGro Status: indirect evidence in vivo Confirmation methods: mutation ID: 280 Notes: Partial inactivation of Gpi14p causes defects in the cell wall structure. Gpi14p is involved in the addition of the first mannose residue to the GPI anchor precursor. | Organism (ID 17016,17027,17028,17029,17030,17031,17032,17033,17034,17035,17036,17037,17038,17039,17040,17041): Saccharomyces cerevisiae FY1679, H1480, E0/YUG37, E37, H3204, H3205, H3211, H3212, H3213, H3238, H3263, H3293, H3296, H3302, BJ10242, BJ5410 Full structure (ID 34887): Molecule role (precursor of): GPI | Orlean et al. 2012 DOI: 10.1534/genetics.112.144485 Imhof et al. 2000 DOI: 10.1093/glycob/10.12.1271 Davydenko et al. 2005 DOI: 10.1002/yea.1286 Subramanian et al. 2006 DOI: 10.1073 pnas.0505570103 Ashida et al. 2005 DOI: 10.1091/mbc.E04–09–0802 Naik at al. 1998 PMID: 9649520 |
| Synthesized dimer: aDManp(1-4)aDGlcpN Donor (ID 34645): ?DManp(1-P-1)Subst // Subst = dolichol Acceptor (ID 34888): lXOco(1-2)[lXOco(1-3),aDGlcpN(1-6)xXmyoIno(1-P-1)]xDGro Status: evidence in vitro Confirmation methods: in vitro (membrane preparation) ID: 281 Notes: The PIG-M homologues from humans, Plasmodium falciparum (PfPIG-M), and Saccharomyces cerevisiae (GPI14) were cloned to test whether they could complement GPI-MT-I-deficient mammalian cells | Organism (ID 9835): Saccharomyces cerevisiae Full structure (ID 34889): Molecule role (precursor of): GPI | Kim et al. 2007 PMID: 17978585 | |
| Synthesized dimer: aDManp(1-4)aDGlcpN Donor (ID 34645): ?DManp(1-P-1)Subst // Subst = dolichol Acceptor (ID 35242): LIP(1-2)[LIP(1-3),Ac(1-2)aDGlcpN(1-6)xXmyoIno(1-P-1)]xDGro Status: indirect evidence in vivo Confirmation methods: mutation (in recombinant protein); expression in S. cerevisiae ID: 507 Notes: Association of PIG-X and PIG-M for GPI-MT-I activity is not interchangeable between mammals and the other lower eukaryotes | Organism (ID 17324): Homo sapiens W303 Expressed in: S. cerevisiae Full structure (ID 34887): Molecule role (precursor of): GPI | Kim et al. 2007b DOI: 10.1093/jb/mvm113 | |
| Synthesized dimer: aDManp(1-4)aDGlcpN Donor (ID 34645): ?DManp(1-P-1)Subst // Subst = dolichol Acceptor (ID 35242): LIP(1-2)[LIP(1-3),Ac(1-2)aDGlcpN(1-6)xXmyoIno(1-P-1)]xDGro Status: indirect evidence in vivo Confirmation methods: mutation (in recombinant protein); expression in S. cerevisiae ID: 508 Notes: Association of PIG-X and PIG-M for GPI-MT-I activity is not interchangeable between mammals and the other lower eukaryotes | Organism (ID 17325): Trypanosoma brucei W303 Expressed in: S. cerevisiae Full structure (ID 34887): Molecule role (precursor of): GPI | ||
| Synthesized dimer: aDManp(1-4)aDGlcpN Donor (ID 34645): ?DManp(1-P-1)Subst // Subst = dolichol Acceptor (ID 35242): LIP(1-2)[LIP(1-3),Ac(1-2)aDGlcpN(1-6)xXmyoIno(1-P-1)]xDGro Status: indirect evidence in vivo Confirmation methods: mutation (in recombinant protein); expression in S. cerevisiae ID: 509 Notes: Association of PIG-X and PIG-M for GPI-MT-I activity is not interchangeable between mammals and the other lower eukaryotes | Organism (ID 17326): Plasmodium falciparum W303 Expressed in: S. cerevisiae Full structure (ID 34887): Molecule role (precursor of): GPI |