Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
The structure was elucidated in this paperNCBI PubMed ID: 8149381Journal NLM ID: 0043535Publisher: Elsevier
Institutions: Gifu Pharmaceutical University, Gifu, Japan
A glucan (AG-HN1, [α]D +24 degrees) and a heteroglycan (AG-HN2, [α]D +26 degrees) were isolated from a hot-water extract of the fruiting bodies of Agrocybe cylindracea. The structures were investigated by a combination of chemical and spectroscopic methods. The results indicated that high molecular weight glucan AG-HN1 is primarily a β-(1-->6)-branched (1-->3)-β-D-glucan containing small amounts of (1-->4)-linked and (1-->6)-linked glucopyranosyl residues. Low molecular weight heteroglycan AG-HN2 gives galactose, glucose, fucose, and mannose on hydrolysis and appears to be chiefly composed of (1-->6)-linked gluco- and galacto-pyranosyl residues, many of them branched, and various nonreducing terminal residues. AG-HN1 showed a remarkable hypoglycemic activity in both normal and streptozotocin-induced diabetic mice by ip administration, and its activity was higher than that of AG-HN2.
Structure type: polymer chemical repeating unit
Location inside paper: AG-HN1, abstract
Trivial name: HA-β-glucan
Compound class: cell wall polysaccharide, glucan
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: gel filtration, 13C NMR, acid hydrolysis, GLC, Smith degradation, paper chromatography, periodate oxidation, methylation analysis, hypoglycemic activity measurement
Comments, role: suggested example structure. Parent molecule: laminarin; small amounts of (1-4) & (1-6) linked glucose residues within the (1-3) backbone, varying degrees of (1-6) branching
Related record ID(s): 45215, 111144, 114427, 118165
NCBI Taxonomy refs (TaxIDs): 64608Reference(s) to other database(s): GTC:G49144DY, CCSD:
39636, CBank-STR:13305
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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