Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.
Bacillus licheniformis, antimicrobial activity, ieodoglucomides, glycolipopeptides, cytotoxic activity
NCBI PubMed ID: 22360451Publication DOI: 10.1021/ol300202zJournal NLM ID: 100890393Publisher: American Chemical Society
Correspondence: shinhj@kordi.re.kr
Institutions: Department of Marine Biotechnology, University of Science and Technology, Daejeon, South Korea, Marine Natural Products Chemistry Laboratory, Korea Ocean Research & Development Institute, Ansan, South Korea
Methods: 13C NMR, 1H NMR, NMR-2D, IR, acid hydrolysis, HPLC, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, cytotoxicity assay, derivatization, antimicrobial assay, MPLC
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