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Structure type: monomer ; 421.1108 [M+Na]+
C₁₈H₂₂O₁₀
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 7263
  Isaka M, Palasarn S, Supothina S, Komwijit S, Luangsa-ard JJ "Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627" - Biotechnology Journal 74(4) (2011) 782-789
  

  A new cyclohexadepsipeptide, conoideocrellide A (1), its linear derivatives, conoideocrellides B-D (2-4), three new hopane triterpenoids (5-7), two new bioxanthracenes (9 and 10), and a new isocoumarin glycoside (13) were isolated from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627. Biological activities of the new compounds were evaluated.

  insect pathogenic fungus

  NCBI PubMed ID: 21473608
  Publication DOI: 10.1021/np100849x
  Journal NLM ID: 101265833
  Publisher: Weinheim: Wiley-VCH Verlag
  Correspondence: isaka@biotec.or.th
  Institutions: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand
  Methods: 13C NMR, 1H NMR, NMR-2D, FTIR, HPLC, UV, extraction, optical rotation measurement, CC, ESI-TOF-MS, melting point determination
  
   
  
  Conoideocrella tenuis BCC 18627
  CSDB ID 43446 (all data & tools)

Show legend Show as text

Structure type: monomer ; 407.0950 [M + Na]+
C₁₇H₂₀O₁₀
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 8788
  Saepua S, Kornsakulkarn J, Somyong W, Laksanacharoen P, Isaka M, Thongpanchang C "Bioactive compounds from the scale insect fungus Conoideocrella tenuis BCC 44534" - Tetrahedron 74(8) (2018) 859-866
  

  Eleven new compounds, including two quinone derivatives of bioxanthracene, conoideocrellones A (1) and B (2), two bioxanthracenes 3 and 4, four isocoumarins and isocoumarin glycosides 7-10, two phenolic compounds 16 and 17, and a diterpenoid compound, conoideocin A (18), were isolated from culture of the scale-insect pathogenic fungus Conoideocrella tenuis BCC 44534. Seventeen known compounds, compounds 5 and 6, ES-242-2 and its atropisomer, isocoumarins and isocoumarin glycosides 11-15, 3,4,6-trihydroxymellein, cis-4,6-dihydroxymellein, metarhizins A (19) and B (20), BR-050 (21), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol, zeorin, and conoideocrellide A, were also isolated from this fungus. Structures of these compounds were elucidated by NMR and MS data analyses. Compound 4 was active against Plasmodium falciparum K1 (IC50 6.6 mu g/mL), while it did not show cytotoxicity. Conoideocrellone A (1) and compounds 3 and 7 exhibited cytotoxic activity, while conoideocin A (18) showed broad range of biological activities including antimalarial, antibacterial, and cytotoxic activities.

  bioactive compounds, Conoideocrella tenuis, bioxanthracenes, isocoumarins, insect fungi

  Publication DOI: 10.1016/j.tet.2018.01.004
  Journal NLM ID: 2984170R
  Publisher: Pergamon Press
  Correspondence: Thongpanchang C
  Institutions: National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand
  Methods: 13C NMR, 1H NMR, acid hydrolysis, FTIR, HPLC, UV, extraction, CC, ESI-TOF-MS, melting point determination, HR-ESI-MS, HMBC, NOESY, antimalarial assays, filtration, optical rotation measurements
  
   
  
  Conoideocrella tenuis BCC 44534
  CSDB ID 49023 (all data & tools)