Show legend Show as text

Structure type: monomer ; 651.3646 [M+Cl]−
C₃₆H₅₆O₈
Trivial name: ganosinoside A
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 7626
  Liu JQ, Wang CF, Li Y, Luo HR, Qiu MH "Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense" - Planta Medica 78(4) (2012) 368-376
  

  A new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid γa (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11-21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, NMR-2D, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-60 cells (IC 50 = 8.30 μM), and ganoderiol E (11) exhibited selective cytotoxic activity against MCF-7 cells (IC 50 = 6.35 μM). Meanwhile, compounds 5, 7, and ganolucidic acids B and C (19, 20) showed induction ability of hPXR-mediated CYP3A4 expression.

  cytotoxicity, CYP3A4 induction, Ganoderma sinense, Ganodermataceae, sesquiterpene, triterpenoids

  NCBI PubMed ID: 22161763
  Publication DOI: 10.1055/s-0031-1280441
  Journal NLM ID: 0066751
  Publisher: George Thieme
  Correspondence: Qiu MH
  Institutions: State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, TLC, ESI-MS, UV, extraction, optical rotation measurement, CC, HR-ESI-MS
  
   
  
  Ganoderma sinense
  CSDB ID 44485 (all data & tools)

Show legend Show as text

Structure type: monomer
Trivial name: ganosinoside A
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 8889
  Peng XR, Su HG, Liu JH, Huang YJ, Yang XZ, Li ZR, Zhou L, Qiu MH "C30 and C31 triterpenoids and triterpene sugar esters with cytotoxic activities from edible mushroom Fomitopsis pinicola (Sw. Ex Fr.) Krast" - Journal of Agricultural and Food Chemistry 67(37) (2019) 10330-10341
  

  Fomitopsis pinicola (Sw. Ex Fr.) Krast has been commonly used as a health food source and antitumor agent. To uncover bioactive key composition of F. pinicola, in our study, we investigated the chemical constituents of a methanol extract of F. pinicola and thirty-five lanostane-type tritetpenoids; 13 new compounds (1-13) and twenty-two known analogues (14-35) were isolated. Among them, compounds 1-9 were C30 lanostane triterpenoids and triterpene sugar esters, while compounds 10-13 were C31 triterpenoids and triterpene sugar esters. Their structures and absolute configurations were elucidated by extensive 1D, 2D NMR, MS, and IR spectra. Furthermore, cytotoxic activities of all isolates against five human tumor cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480) were evaluated. The results showed that compounds 12, 14, 17, 18, 22, and 23 displayed cytotoxic effects against five human tumor cell lines with IC50 values ranging from 3.92-28.51 μM. Meanwhile, compounds 9 and 35 exhibited selected inhibitory activities against HL-60, SMMC-7721, and MCF-7 with IC50 values in the range of 13.57-36.01 μM. Furthermore, the flow cytometry analysis revealed that compounds 17, 22, and 35 induced apoptosis in HL-60 cell lines. Their structure-activity relationships were preliminarily reported. These findings indicate the vital role of triterpenoids and their glycosides in explaining antitumor effects of F. pinicola and provide important evidence for further development and utilization of this fungus.

  cytotoxic activity, Polyporaceae, C30 triterpenoids, C31 triterpenoids

  NCBI PubMed ID: 31469960
  Publication DOI: 10.1021/acs.jafc.9b04530
  Journal NLM ID: 0374755
  Publisher: American Chemical Society
  Correspondence: Qiu MH
  Institutions: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China, University of the Chinese Academy of Science, Beijing, China
  Methods: 13C NMR, 1H NMR, IR, TLC, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CD, CC, HR-ESI-MS, cytotoxicity assay, evaporation, UPLC-DAD/MS
  
   
  
  Fomitopsis pinicola
  CSDB ID 49645 (all data & tools)