In this paper, microbial transformation of kurarinone (1) by Cunninghamella echinulata AS 3.3400 was investigated and four transformed products were isolated and identified as 6″-hydroxykurarinone (2), 4″,5″,8″-trihydroxynorkurarinone (3), norkurarinone (4), and kurarinone-7-O-β-glucoside (5), respectively. Among them, 3 and 5 are new compounds, and the rare glycosylation in microbial transformation was observed. In addition, the cytotoxicities of transformed products (2-5) were also investigated.
flavonoid, biotransformation, kurarinone, Cunninghamella echinulata AS 3.3400
NCBI PubMed ID: 23009297Publication DOI: 10.1080/10286020.2012.681049Journal NLM ID: 100888334Publisher: Harwood Academic Publishers; London: Informa Healthcare
Correspondence: Yuan QP
; Ma XC
Institutions: School of Pharmacy, Dalian Medical University, Dalian, China, College of Bioengineering, Beijing Polytechnic, Beijing, China, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
Methods: 13C NMR, 1H NMR, IR, TLC, UV, extraction, CD, cell growth, melting point determination, FTICR-MS
Found