The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease
ergosterol derivatives, Dichotomomyces cejpii, Alzheimer’s disease
NCBI PubMed ID: 26440473Publication DOI: 10.1016/j.steroids.2015.09.012Journal NLM ID: 0404536Publisher: Elsevier
Correspondence: g.koenig@uni-bonn.de
Institutions: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany, ManRos Therapeutics, Centre de Perharidy, Roscoff, France
Methods: 13C NMR, 1H NMR, NMR-2D, IR, ESI-MS, acid hydrolysis, biological assays, HPLC, UV, extraction, optical rotation measurement, cell growth, HR-ESI-MS, sonication, VLC
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