Oriental crude drug, Bombyx Batryticatus, is dried silkworm larva, Bombyx mori L., which are dead and stiffened due to a Beauveria bassiana infection. In traditional Japanese, Korean, and Chinese medicine, it is employed as analgesic and anticonvulsant. We investigated the constituents of Bombyx Batryticatus and isolated four novel aromatics bearing 4-O-methylglucose moiety, BB-1, 2, 3, and 4 (1-4). It is speculated that these compounds are produced by an interaction between plants, insects, and microorganisms
Beauveria bassiana, microbial biotransformation, Bombyx Batryticatus, silkworm, biological interaction
Publication DOI: 10.1016/j.tetlet.2003.10.159Journal NLM ID: 2984819RPublisher: Elsevier
Correspondence: oshima@mail.pharm.tohoku.ac.jp
Institutions: Laboratory of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Japan
Methods: 13C NMR, 1H NMR, EI-MS, FAB-MS, acid hydrolysis, HPLC, alkaline hydrolysis, extraction, acetylation, CD, CC, COSY, HR-EI-MS