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Schweda EK, Richards JC, Hood DW, Moxon ER
Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence
International Journal of Medical Microbiology 297(5) (2007)
297-306
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EtN-(1-6)-+ b-D-Glcp-(1-4)-+ EtN-(1---P---P---4)-+
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L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2--/lipid A/ |
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Haemophilus influenzae
(NCBI TaxID 727,
species name lookup)
Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Haemophilus influenzae [ICD11:
XN1P6 
]
NCBI PubMed ID: 17452015Publication DOI: 10.1016/j.ijmm.2007.03.007Journal NLM ID: 100898849Publisher: Jena, Germany: Urban & Fischer Verlag
Correspondence: elke.schweda
crc.ki.se
Institutions: Clinical Research Centre, Karolinska Institutet and University College of South Stockholm, NOVUM, S-141 86 Huddinge, Sweden
Lipopolysaccharide (LPS) is a major virulence determinant of the human bacterial pathogen Haemophilus influenzae. A characteristic feature of H. influenzae LPS is the extensive intra- and inter-strain heterogeneity of glycoform structure which is key to the role of the molecule in both commensal and disease-causing behaviour of the bacterium. Through the combination of genetics and detailed structural analyses, H. influenzae is an exemplar Gram-negative bacterium for which now the most extensive and detailed LPS structural data and functional correlates are available. LPS from H. influenzae consists of a conserved glucose-substituted triheptosyl inner-core moiety L-α-D-Hepp-(1→2)-[PEtn→6]-L-α-D-Hepp-(1→3)-[β-D-Glcp-(1→4)]-L-α-D-Hepp linked to lipid A via Kdo 4-phosphate. The inner-core unit provides the template for attachment of oligosaccharide- and non-carbohydrate substituents. Here, the structure, genetics and expression of LPS glycoforms in the outer core are reviewed as well as their implication on virulence
Lipopolysaccharide, Haemophilus influenzae, molecular mimicry, Phosphocholine, sialic acid, Digalactoside
Structure type: oligomer
Location inside paper: p.298, Structure 1
Aglycon: lipid A
Compound class: inner core
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_142488,IEDB_146664,IEDB_2189047,IEDB_983931,SB_192
Biological activity: serological data, biological activity data
Biosynthesis and genetic data: genetic data, biochemical data
Comments, role: conserved glucose-substituted triheptosyl inner-core LPS from Haemophilus influenzae
Related record ID(s): 21824, 21825, 21826, 21827, 21828, 21829, 21830, 21831, 21832, 21833, 21834, 21835, 21836, 21837, 21838
NCBI Taxonomy refs (TaxIDs): 727
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Kobayashi H, Kojimahara T, Takahashi K, Takikawa M, Takahashi SI, Shibata N, Okawa Y, Suzuki S
Structural determination of D-mannans of pathogenic yeasts Candida stellatoidea Type I strains: TIMM 0310 and ATCC 11006 compared to IFO 1397
Carbohydrate Research 214 (1991)
131-145
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Subst1-(1-?)-Subst-(?-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc1N-(1-4)-Asn-(?--/protein/
Subst = inner core;
Subst1 = ID116250/ID116251/ID116252 |
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Candida stellatoidea I IFO 1397
(Ancestor NCBI TaxID 5476,
species name lookup)
Candida stellatoidea I TIMM 0310
(Ancestor NCBI TaxID 5476,
species name lookup)
Candida stellatoidea I ATCC 11006
(Ancestor NCBI TaxID 5476,
species name lookup)
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
NCBI PubMed ID: 1954627Journal NLM ID: 0043535Publisher: Elsevier
Institutions: Second Department of Hygienic Chemistry, Tohoku College of Pharmacy, Miyagi, Japan, Second Department of Hygienic Chemistry, Tohoku College of Pharmacy, Miyagi, Japan.
The structures of the cell-wall D-mannans of pathogenic yeasts of Candida stellatoidea Type I strains, IFO 1397, TIMM 0310, and ATCC 11006, were investigated by mild acid and, alkaline hydrolysis, by digestion with the Arthrobacter GJM-1 strain exo-α-D-mannosidase, and by acetolysis. The modified D-mannans and their degradation products were studied by 1H- and 13C-n.m.r. analyses. D-Manno-oligosaccharides released by acid treatment from the parent D-mannans were identified as the homologous β-(1----2)-linked D-manno-oligosaccharides from biose to hexaose, whereas those obtained by alkaline degradation were the homologous α-(1----2)-linked D-mannobiose and D-mannotriose. The acid- and alkali-modified D-mannans lacking 1H-n.m.r. signals above 4.900 p.p.m. [corresponding to β-(1----2)-linked D-mannopyranose units] were acetolyzed with 10:10:1 (v/v) Ac2O-AcOH-H2SO4, and the resultant D-manno-oligosaccharides were also analyzed. It was found that the longest branches of these D-mannans, corresponding to hexaosyl residues, had the following structures: α-D-manp-(1----3)-α-D-manp-(1----2)-α-D-manp+ ++-(1----2)-α-D-manp- (1----2)-α-D-manp-(1----2)-D-Man and α-D-manp-(1----2)-α-D-manp-(1----3)-α-D-manp+ ++-(1----2)-α-D-manp- (1----2)-α-D-manp-(1----2)-D-Man. These results indicate that the D-mannans of C. stellatoidea Type I strains possess structures in common with the D-mannans of Candida albicans serotype B strain (see ref. 4) containing phosphate-bound β-(1----2)-linked oligo-D-mannosyl residues.
Structure type: oligomer
Location inside paper: figure 7 (A,B,C)
Aglycon: protein
Compound class: N-glycan, inner core
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531
Methods: gel filtration, 13C NMR, 1H NMR, enzymatic digestion, acetolysis, slide-agglutination reaction, acid and alkaline hydrolysis
Comments, role: core structure to which the possible outer structure is attached (ID116250, ID116251, or ID116252)
Related record ID(s): 116241, 116242, 116243, 116244, 116245, 116246, 116247, 116248, 116249, 116250, 116251, 116252, 116253, 266250
NCBI Taxonomy refs (TaxIDs): 5476
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