Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: cystic fibrosis (CF) [ICD11:
CA25 
]
NCBI PubMed ID: 36716692Publication DOI: 10.1016/j.carres.2023.108741Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: J.W. Brady <jwb7
cornell.edu>
Institutions: Department of Food Science, Cornell University, Ithaca, NY, 14853, USA
Potential of Mean Force Ramachandran energy maps in aqueous solution have been prepared for all of the glycosidic linkages found in the C1576 exopolysaccharide from the biofilms of the bacterial species Burkholderia multivorans, a member of the Burkholderia cepacian complex that was isolated from a cystic fibrosis patient. C1576 is a rhamnomannan with a tetrasaccharide repeat unit. In general, for the four linkage types in this polymer, hydration did not produce dramatic changes in the Ramachandran energy surfaces, with the 3-methyl-α-d-rhamnopyranose-(1→3)-α-d-rhamnopyranose case exhibiting the greatest hydration change, with the global minimum energy conformation shifting by more than 80° in ψ. However, hydration did reduce the rigidity of all the linkages, increasing the overall flexibility of this polysaccharide.
exopolysaccharide, biofilms, Burkholderia multivorans, Polysaccharide Ramachandran conformational energy maps, free energy conformational maps, potentials of mean force
Structure type: polymer chemical repeating unit
Location inside paper: p. 108741-1
Trivial name: rhamno-mannan, rhamnomannan, Epol C1576
Compound class: EPS
Contained glycoepitopes: IEDB_130701,IEDB_136104,IEDB_1394181,IEDB_143632,IEDB_144983,IEDB_145010,IEDB_152206,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
Methods: molecular mechanics, CHARMM program, CHARMM36, PMF calculation, WHAM
NCBI Taxonomy refs (TaxIDs): 87883Reference(s) to other database(s): GTC:G72472ZR
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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