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Structure type: monomer ; 530.60
C₃₀H₄₂O₈
Trivial name: proscillaridin A
Compound class: glycoside, terpenoid glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823

• Article ID: 9164
  Lau MF, Chua KH, Sabaratnam V, Kuppusamy UR "In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells" - Biotechnology and Applied Biochemistry 2020 (2020) ID 2013
  

  Ganoderma neo-japonicum is a well-known medicinal mushroom in Asian countries. However, scientific validations on its curative activities are confined to cirrhosis and diabetes. In this study, the anticancer properties of G. neo-japonicum were evaluated using cellular and computational models. The ethanolic extract (EtOH) with a promising inhibitory effect was fractionated into four different fractions: hexane (Hex), chloroform (Chl), butanol (Btn), and aqueous (Aq). The active fractions were then subjected to cell apoptosis assessment and phytochemical profiling. Molecular docking was conducted to elucidate the affinity of selected constituents towards antiapoptotic Bcl-2 protein. The butanol fraction showed the highest antioxidant activities as well as total phenolic content. Both hexane and chloroform fractions exerted a potent cytotoxic effect on colonic carcinoma cells through the induction of apoptosis. Phytochemical analysis revealed that the chloroform fraction is terpenoid enriched whereas the hexane fraction comprises predominantly sterol constituents. Stellasterol and 1,25-dihydroxyvitamin D3 3-glycoside were demonstrated to have a high affinity towards Bcl-2 protein. Overall, G. neo-japonicum can be considered as a compelling therapeutic candidate for cancer treatment.

  apoptosis, Antioxidant, molecular docking, Anticancer, Ganoderma neo-japonicum

  NCBI PubMed ID: 32856730
  Publication DOI: 10.1002/bab.2013
  Journal NLM ID: 8609465
  Correspondence: Kuppusamy UR
  Institutions: Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia, Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  Methods: GC-MS, extraction, LC-MS, cell growth, antioxidant activities, cell viability assay, radical scavenging assay, evaporation, MTT, filtration, apoptosis assay, binding assay, Folin phenol reagent method
  
   
  
  Ganoderma neo-japonicum
  CSDB ID 50415 (all data & tools)

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Structure type: monomer
C₃₀H₄₂O₈
Trivial name: proscillaridin A, talusin
Compound class: glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823

• Article ID: 9165
  Gould L, Fisch S, Cherbakoff A, DeGraff AC "Clinical studies on proscillaridin, a new squill glycoside" - Journal of Clinical Pharmacology and New Drugs 11(2) (1971) 135-145
  

  Proscillaridin (talusin) is a pure crystalline glycoside obtained from the white squill (Urginea maritinia linne). It has been identified as the 3β-rhamnosido-14β-hydroxybufa-4,20,22-trienolide.·Its chemical structure is shown in Fig. 1. The drug is well absorbed from the gastrointestinal tract, thus permitting rapid oral action. It has been used extensively in Europe, and its reported main advantage is its relatively rapid speed of dissipation. This should minimize toxicity associated with inadvertent overdosage. A rapidly dissipated cardiac glycoside, effective orally, and similar in its cardiotonic effects to available glycosides would indeed be welcome. This study will show that proscillaridin is an effective cardiotonic agent both orally and intravenously, that it is rapidly dissipated, and that its toxicity is similar to that of commonly used glycosides

  proscillaridin, Urginea maritinia, white squill

  NCBI PubMed ID: 4929290
  Publication DOI: 10.1177/009127007101100209
  Journal NLM ID: 0366131
  Publisher: Stamford Ct: Hall Associates
  Institutions: Cardiac Therapy Research Unit, Veterans Administration Hospital, Bronx, USA
  Methods: biological assays
  
   
  
  Urginea maritinia
  CSDB ID 50418 (all data & tools)