One new terphenyl glycoside (1), gliocladinin D, together with 4 known compounds (2-5) were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). The structure of the new compound was elucidated by the comprehensive spectroscopic analysis, including 1-dimensional and 2-dimensional nuclear magnetic resonance, and high-resolution electrospray ionization mass spectrometry. Compound 3 exhibited moderate Topo I inhibitory activity.
Trichoderma reesei, phenolics, sponge-derived fungus, terphenyl glycoside, Topo I inhibitory activity
Publication DOI: 10.1177/1934578X20907753Journal NLM ID: 101477873Publisher: Natural Product Communications
Correspondence: Wang C-Y
Institutions: Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China, Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China, Department of Pharmacy, Faculty of Medical & Health Sciences, University of the Poonch, Rawalakot, Pakistan
Methods: 13C NMR, 1H NMR, IR, inhibition studies, ESI-MS, acid hydrolysis, HPLC, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, enzymatic assay, antibacterial assay, cytotoxicity assay, evaporation, VLC
Found