A new isopimarane-type diterpene glycoside, named hypomonticuside (1), was isolated from the BuOH-soluble fraction of the liquid fermentation of an endophytic fungus Corynespora smithii, derived from the stems of Ardisia cornudentata Mez (Myrsinaceae). The structure of 1 was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques.
secondary metabolite, diterpene, Xylariaceae, Hypoxylon monticulosum
Publication DOI: 10.1007/s10600-020-03060-9Journal NLM ID: 0047757Publisher: New York: Kluwer Academic/Plenum Publishers
Correspondence: Cheng MJ
Institutions: Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu, Taiwan, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Pathology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan, Department of Neurosurgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
Methods: 13C NMR, 1H NMR, EI-MS, NMR-2D, IR, DNA techniques, TLC, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, RP-MPLC