A novel 3,4-dihydroisocoumarin glycoside (1) was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron, together with five known compounds (2–6). Their structures elucidations were conducted by HRESIMS, NMR and IR spectroscopic analysis. All the isolated compounds were evaluated for their antimicrobial, anti-tumor, and anti-HIV-1 activities. Compound 1 only displayed weak antimicrobial activity against micrococcus luteus. The other known compounds showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.
structure, antimicrobial activity, fungus, Xylaria, xylaphenoside
NCBI PubMed ID: 36806196Publication DOI: 10.1038/s41429-022-00586-8Journal NLM ID: 0151115Publisher: London: Nature Publishing Group
Correspondence: M. Ge
; Y. Xu
Institutions: School of Pharmacy, Shanghai University of Medine&Health Sciences, Shanghai, China, Microbial Pharmacology Laboratory, Shanghai University of Medine & Health Sciences, Shanghai, China, Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China
Methods: 13C NMR, 1H NMR, IR, sugar analysis, inhibition studies, acid hydrolysis, GC, extraction, CD, RP-HPLC, fermentation, HR-ESI-MS, antibacterial assay, cytotoxicity assay, isolation
Found