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Structure type: oligomer
Trivial name: 20(R)-ginsenoside-Rg3
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 9782
  Takemoto Y, Ueyama T, Saito H, Horio S, Sanada S, Shoji J, Yahara S, Tanaka O, Shibata S "Potentiation of nerve growth factor-mediated nerve fiber production in organ cultures of chicken embryonic ganglia by ginseng saponins: structure-activity relationship" - Chemical and Pharmaceutical Bulletin 32(8) (1984) 3128-3133
  

  Potentiation of the nerve growth factor (NGF)-mediated nerve fiber production in organ cultures of chicken embryonic dorsal root ganglia (DRG) and lumbar sympathetic ganglia (SymG) by saponins isolated from Panax ginseng C. A. MAYER and Panax japonicum C. A. MAYER and related compounds was studied in order to elucidate the structure-activity relationship. Panax saponins and related compounds so far tested did not promote nerve fiber production, but some 20 (S)-protopanaxadiol glycoside having glucose units in their two sugar moieties potentiated the effect of NGF. Removal of glucose or introduction of a hydroxy group into the side chain of ginsenoside Rd reduced the activity. Little difference was observed in the potentiation of the NGF effect by the saponins in organ cultures of DRG and SymG.

  tissue culture, Panax ginseng, saponin, nerve growth factor

  NCBI PubMed ID: 6518590
  Publication DOI: 10.1248/cpb.32.3128
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: School of Pharmaceutical Sciences, Showa University, Tokyo, Japan, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Tokyo, Japan, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima Japan, Meiji College of Pharmacy, Tokyo, Japan
  Methods: nerve fiber production test
  
   
  
  Panax ginseng, Panax japonicum
  CSDB ID 119228 (all data & tools)
• Article ID: 10728
  Samukawa K, Yamashita H, Matsuda H, Kubo M "Simultaneous analysis of saponins in Ginseng Radix by high performance liquid chromatography" - Chemical and Pharmaceutical Bulletin 43 (1995) 137-141
  

  The presence of about 25 ginsenosides in Ginseng Radix and their structures have already been elucidated. Although some important neutral- and acidic-saponins have been detected by high performance liquid chromatography (HPLC), other saponins have not yet been examined by HPLC. Our present improved method for the detection of ginsenosides by HPLC with a C_<18> column and a CH_3CN-H_2O gradient system enabled the measurement of not only the representative ginsenosides in Red Ginseng [20(R)-ginsenoside-Rg_2 and -Rh_1,20(S, R)-ginsenosides-Rg_3 and -Rs_1] but also the minor ginsenosides [ginsenosides-Rb_3,-Rg_2,-Rh_1 and quinquenoside-R1]. Furthermore, the application of this method after a little modification of the eluent in particular to an extract of Ginseng Radix achieved simultaneous separation of 22 neutral- and acidic-ginsenosides. The qualitative and quantitative analysis of ginsenosides using the present method offers an efficient means of evaluating Ginseng Radix and commercial products containing it.

  Panax ginseng, Ginseng saponin, simultaneous HPLC analysis, Ginseng Radix, White Ginseng, Red Ginseng

  Journal NLM ID: 0377775
  WWW link: http://ci.nii.ac.jp/naid/110003631301
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Faculty of Pharmaceutical Sciences, Kinki University, Japan, Ginseng Institute, Japan Korea Red Ginseng Co., Ltd., Japan
  Methods: HPLC
  
   
  
  Panax ginseng
  CSDB ID 120549 (all data & tools)