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Structure type: oligomer ; 961 [M-H]-
C₄₈H₈₂O₁₉
Trivial name: vina-ginsenoside-R9
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 10501
  Duc NM, Kasai R, Ohtani K, Ito A, Nham NT, Yamasaki K, Tanaka O "Saponins from Vietnamese Ginseng, Panax vietnamensis HA et GRUSHV. collected in central Vietnam. II" - Chemical and Pharmaceutical Bulletin 42(1) (1994) 115-122
  

  Further investigation on the saponin composition of rhizomes and roots of Panax vietnamensis HA et GRUSHV. has resulted in the isolation and structural elucidation of seven new dammarane saponins named vina-ginsenosides-R3 (12), -R4 (11), -R5 (16), -R6 (17), -R7 (6), -R8 (20), -R9 (22), together with the identification of six of known saponins including 20-gluco-ginsenoside-Rf (10), ginsenoside-Rc (4), notoginsenoside-R6 (9), quinquenoside-R1 (5), gypenoside XVII (2) and majoroside F1 (21). The structures of the novel saponins were established on the basis of chemical and spectral evidence. Vina-ginsenoside-R3 is the first naturally occurring glycoside of dammarenediol II, while vina-ginsenosides-R5 and -R6,two ocotillol-type saponins, are two other examples of saponins having the rare α-glucosyl linkage.

  ginsenoside, Vietnamese Ginseng, Panax vietnamensis, dammarane saponin, vina-ginsenoside-R3, vina-ginsenoside-R4, vina-ginsenoside-R5, vina-ginsenoside-R6, vina-ginsenoside-R7, vina-ginsenoside-R8, vina-ginsenoside-R9, dammarenediol saponin

  NCBI PubMed ID: 8124758
  Publication DOI: 10.1248/cpb.42.115
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh City University of Medicine and Pharmacy, Vietnam, Institute of Pharmaceutical Sciences, Hiroshima Univeristy School of Medicine, Japan, Suzugamine Women's College, Japan
  Methods: 13C NMR, 1H NMR, EI-MS, gel filtration, FAB-MS, partial acid hydrolysis, HPLC, enzymatic digestion, acetylation analysis, photosensitized oxydation
  
   
  
  Panax vietnamensis
  CSDB ID 120325 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: vina-ginsenoside R9
Compound class: glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 12848
  Yamasaki K "Bioactive saponins in Vietnamese ginseng, Panax vietnamensis" - Pharmaceutical Biology (2000) 16-24
  

  Vietnamese ginseng, Panax vietnamensis was recently found in central Vietnam, and regarded as a new botanical species. It was used in traditional folk medicine in hill tribes for the purpose of anti-fatigue and life saving. From the rhizome and root of this plant, 37 saponins including 14 new compounds were isolated. Some of them were common to other Panax spp., but the general yields in this species were very high. Among them, an ocotillol-type saponin majonoside-R2 (MR2) was remarkable in its yield (5.3%). Structural features of new saponins were briefly introduced. The biological effects of these saponins were studied in two ways, anti-stress effect and anti-tumor promoting effect; both activities were based upon the traditional usage of this crude drug. In psychologically stressed mice, the saponin fraction of Vietnamese ginseng significantly reduced stress-related disorders (reducing sleeping time, formation of gastric lesions) and MR2 was responsible for this effect. A possible mechanism for this effect was proposed. MR2 exhibited a significant inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol acetate. MR2 also showed potent anti-tumor-promoting activity on mouse skin and hepatic tumors.

  Vietnamese Ginseng, Panax vietnamensis, dammarane saponin, majonoside-R2, cancer chemoprevention, adaptogen, antistress, anti-tumor promotion, ocotillol, vinaginsenoside

  NCBI PubMed ID: 23531134
  Publication DOI: 10.1076/phbi.38.6.16.5956
  Journal NLM ID: 9812552
  Publisher: Lisse, the Netherlands: Swets & Zeitlinger
  Correspondence: yamasaki@pharm.hiroshima-u.ac.jp
  Institutions: Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
  
   
  
  Panax vietnamensis
  CSDB ID 68717 (all data & tools)