Bioactivity-guided fractionation of extracts of the aerial parts of Jasminum azoricum var. travancorense, using an in vitro ACE inhibition assay, led to isolation of three oligomeric, iridoid-type compounds, which were named sambacein I-III. Their structures are based on spectroscopic and chemical evidence. Similarly, fractionation of extracts of aerial parts of J. grandiflorum resulted in the isolation of the previously reported ACE inhibitor, oleacein. The IC50 values of purified ACE inhibitors were 26-36 microM. Moreover, 2-(3,4-dihydroxyphenyl)-ethanol, isoquercitrin and ursolic acid were isolated from J. grandiflorum. Sambaceins and oleacein are formed from genuine iridoid glucosides during processing of the plant material. NMR spectroscopy was used to measure the level of the ACE inhibitors in the traditional medicines prepared in Kerala from these Jasminum species.
phenylethanoid glycoside, Scrophulariaceae, phenylpropanoid glycosides, iridoid glucosides, Iridoids, Pedicularis artselaeri
NCBI PubMed ID: 17253316Publication DOI: 10.1055/s-2006-957565Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: Jia ZJ
Institutions: Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China
Methods: 13C NMR, 1H NMR, IR, FAB-MS, acid hydrolysis, methanolysis, HPLC, UV, extraction, optical rotation measurement, CC, DEPT
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