The 50% aqueous methanolic extract from the bark of Betula platyphylla SUKATCHEV var. japonica (MIQ) HARA was found to show potent inhibitory activity on the liver-injury induced by CCl4 or D-galactosamine (D- GalN)/lipopolysaccharide as well as O2- scavenging and antioxidative activities. From the 50% aqueous methanolic extract, two new diarylheptanoids named betulaplatosides Ia (1) and Ib (2) and a new arylbutanoid named betulaplatoside II (3) were isolated together with seventeen known aromatic constituents. 1, 2, and two known diarylheptanoids [(5S)-5-hydroxy-1,7-bis- (4-hydroxyphenyl)-3-heptanone 5-O-β-D-apiofurano-syl-(1→6)-β-D- glucopyranoside (6) and aceroside VIII (7)] showed protective activity against D-GaIN-induced cytotoxicity in primary cultured rat hepatocytes. Furthermore, several aromatic constituents exhibited potent O2- scavenging and antioxidative activities.
mice, Animals, Plant Extracts, Antioxidants, free radical scavengers, liver, Betula platyphylla, Betula
NCBI PubMed ID: 9873651Publication DOI: 10.1016/S0960-894X(98)00528-9Journal NLM ID: 9107377Publisher: Elsevier
Institutions: Kyoto Pharmaceutical University, Kyoto, Japan, Sunstar Inc., Takatsuki, Japan
Methods: 13C NMR, 1H NMR, IR, FAB-MS, enzymatic hydrolysis, acid hydrolysis, GLC, biological assays, HPLC, UV, extraction, optical rotation measurement, CC, antioxidant activities, HMBC, radical scavenging assay, NaNH4 reduction, opitcal rotation measurement, enzymatic hidrolysis
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