Suspension cultures of Vitis vinifera L. (Vitaceae) produce many hydroxylated stilbene glucosides found in red wine. From these cells, we isolated and characterized glycosylated stilbenes, (Z)-piceatannol (3,5,3',4'-tetrahydroxystilbene)-3-O-β-D-glucopyranoside (6) and (E)and (Z)- resveratrol (3,5,4'-trihydroxystilbene)-4'-O-β-D-glucopyranoside (2 and 7, respectively), which have not previously reported to be constituents of Vitis vinifera or wine. The ability of these compounds to act as radical scavengers was investigated using 1,1 diphenyl-2-picryl-hydrazyl, a stable free radical. Antioxidant activities were assessed by their capacity to prevent Cu2+- induced lipid peroxidation in human low-density lipoprotein.
Vitis vinifera, piceatannol, resveratrol glucopyranoside, stilbene derivative
NCBI PubMed ID: 9599270Publication DOI: 10.1021/np9704819Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Merillon J
Institutions: Groupe d'Etude des Substances Naturelles à Intérêt Thérapeutique, Faculté des Sciences Pharmaceutiques, Université de Bordaux, Bordeaux, France, Centre d'Etudes et de Recherche sur les Xénobiotiques, Faculté de Médicine et de Pharmacie, Université de Poitiers, Poitiers, France
Methods: IR, HPLC, UV, extraction, CC, antioxidant activities, HMBC, HMQC, COSY
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