Xanthorrhizol, xanthorrhizol glycoside, and trachylobanoic acid, compounds isolated from medicinal plants that are grouped in the complex known as Cachani have been shown to inhibit the tonic contraction of rat uterus induced by: (a) depolarizing K+ solution (60 mM), (b) CaCl2 (1 mM), and (c) BAY K 8644 (0.3 μM) in a concentration-dependent manner (1-30 μg/mL). The inhibitory potency was displayed as follows: xanthorrhizol >, xanthorrhizol glycoside >, trachylobanoic acid. These results suggest that the assayed compounds might block voltage operated calcium influx in myometrial cells as they displayed a calcium-antagonistic activity. This effect is not due to peripheral receptor activation (β2-adrenergic, H2-histaminergic) as neither propranolol nor cimetidine modified the inhibitory effect of the compounds assayed. This is the first report showing that plants belonging to the Cachani complex may contain uterine smooth muscle bioactive substances.
Cachani complex, xanthorrhizol, trachylobanoic acid, rat uterus
NCBI PubMed ID: 10353157Publication DOI: 10.1002/(SICI)1099-1573(199905)13:3<202::AID-PTR418>3.0.CO;2-RJournal NLM ID: 8904486Publisher: Chichester: Wiley
Institutions: Unidad de Investigacion Medica en Farmacologia, Centro Medico Nacional, Siglo XXI, Instituto Mexicano del Seguro Social, Apartado Postal 73-032, 03020, Mexico, Departamento de Farmacia, Division de Estudios de Posgrado, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico, Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Mexico
Methods: extraction
Found