Found 2 structures.
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1. Compound ID: 31387
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a-L-Rhap-(1-6)-b-D-Galp-(1-3)-Subst
Subst = 3,5,6,7,8,4'-hexahydroxyflavone = SMILES O=c({3}c(O)c(c1cc{54}c(O)cc1)o2)c3c2{8}c(O){7}c(O){6}c(O){5}c3O |
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Structure type: oligomer
Compound class: glycoside, flavonoid glycoside
Contained glycoepitopes: IEDB_136044,IEDB_136105,IEDB_137472,IEDB_141794,IEDB_190606,IEDB_225177,IEDB_885823,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 12052
Capasso A, Saturnino P, Simone FD, Aquino R "Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro" -
Phytotherapy Research 14(7) (2000) 538-540
The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.
guinea-pig ileum, Aristeguietia discolor, morphine, naloxone
NCBI PubMed ID: 11054845Publication DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1Journal NLM ID: 8904486Publisher: Chichester: Wiley
Correspondence: Capasso A
Institutions: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
Methods: biological assays
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2. Compound ID: 31388
|
a-L-Rhap-(1-6)-b-D-Glcp-(1-3)-Subst
Subst = 3,5,6,7,8,4'-hexahydroxyflavone = SMILES O=c({3}c(O)c(c1cc{54}c(O)cc1)o2)c3c2{8}c(O){7}c(O){6}c(O){5}c3O |
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Structure type: oligomer
Compound class: glycoside, flavonoid glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 12052
Capasso A, Saturnino P, Simone FD, Aquino R "Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro" -
Phytotherapy Research 14(7) (2000) 538-540
The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.
guinea-pig ileum, Aristeguietia discolor, morphine, naloxone
NCBI PubMed ID: 11054845Publication DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1Journal NLM ID: 8904486Publisher: Chichester: Wiley
Correspondence: Capasso A
Institutions: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
Methods: biological assays
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