Since some Solanum-genus plants have traditionally been used for anti-cancer and anti-herpes agents from olden times, we examined anti-herpes simplex virus type 1 (HSV-1) activity of typical steroidal glycosides with the frameworks of spirostane (including nuatigenin glycoside), furostane, solasodane, tomatidane and ergostane (including dimer) obtained from Solanum plants. Among these steroidal glycosides, the spirostanol glycosides were most effective. An inclination was observed for the potency of activity to decrease in the order of spirostane, tomatidane, ergostane, solasodane, nuatigenin type, dimer of ergostane and furostane. It was also suggested that the activity depends on the kind of oligosacchride moiety.
steroidal glycoside, anti-herpes simplex virus activity, Solanum-genus
NCBI PubMed ID: 10726897Publication DOI: 10.1248/bpb.23.363Journal NLM ID: 9311984Publisher: Pharmaceutical Society of Japan
Correspondence: Nohara T
Institutions: Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Laboratory of Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Methods: biological assays, cytotoxicity assay, antiviral assay
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