Two new anthraquinone glucosides [chrysophanol 8-O-β-d-(6′-galloyl)-glucopyranoside, aloe-emodin 1-O-β-d-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-β-d-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2′′-O-gallate, rhaponticin 6′′-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages. (IC50=11–69 μM). The oxygen functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the α,β-double bond did not affect the activity. Furthermore, the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction.
stilbene glucosides, Rheum undulatum, rhubarb, anthraquinone glucosides, inhibition of NO production
NCBI PubMed ID: 10714491Publication DOI: 10.1016/s0960-894x(99)00702-7Journal NLM ID: 9107377Publisher: Elsevier
Correspondence: Yoshikawa M
Institutions: Kyoto Pharmaceutical University, Kyoto, Japan
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