A chemical investigation of the aerial parts of Polianthes tuberosa resulted in the isolation of a new bisdesmosidic cholestane glycoside (1) and three new spirostanol saponins (2-4), along with a known cholestane glycoside. The structures of new glycosides were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity on HL-60 human promyelocytic leukemia cells.
cytotoxicity, steroidal glycosides, Polianthes tuberosa, HL-60 leukemia cells
NCBI PubMed ID: 11087596Publication DOI: 10.1021/np000230rJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: mimakiy@ps.toyaku.ac.jp
Institutions: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
Methods: 13C NMR, 1H NMR, EI-MS, NMR-2D, TLC, HPLC, extraction, evaporation, centrifugation, HR-EI-MS
Found