Two new triterpenoid saponins, glinosides A and B, isolated from the aerial parts of Glinus oppositifolius, have been characterized by 1D, 2D, NMR and high-resolution mass spectral (HRMS) techniques. Their structures were established respectively as 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,21β,22-tetrahydroxyhopane for glinoside A and 16-O-(β-arabinopyranosyl)-3-oxo-12,16β,22-trihydroxyhopane for glinoside B. Results presented evidence that fractions had a better antiplasmodial activity (IC50 = 31.80 μg/ml) than pure glinoside A (IC50 = 42.30 μg/ml).
Glinus oppositifolius, glinosides A and B, hopane triterpenoids
NCBI PubMed ID: 10865459Publication DOI: 10.1055/s-2000-8551Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: Evelyne-Ollivier@pharmacie.univ-mrs.fr
Institutions: Laboratoire de Pharmacognosie, Faculté de Pharmacie, Marseille, France, INRA Centre de Recherche de Toulouse, Laboratoire des Xénobiotiques, Toulouse, France, ESA 6009, Université d'Aix Marseille III, Marseille, France, Laboratoire de Parasitologie, Faculté de Pharmacie, Marseille, France, Département de Médecine Traditionelle, Bamako, Mali
Methods: 13C NMR, 1H NMR, NMR-2D, FAB-MS, TLC, ESI-MS, biological assays, HPLC, extraction, CC
Found