Roots of Phyllanthus acidus Skeels have frequently been used in the rehabilitation program for alcoholic addicts in Thailand. The use of the spirit extract of this plant in treating alcoholism is reported to be very effective against the craving for alcohol. However, many patients have later encountered serious side effect in the form of chronic illness; this has prompted us to explore chemicals in the roots of P. acidus. We report here the novel cytotoxic water-soluble norbisabolane glycosides, named phyllanthusol A (1) and phyllanthusol B (2), isolated from the MeOH extract of the roots of P. acidus; these substances might be responsible for the illness of patients who have been treated with the root extract of P. acidus.
cytotoxicity, Phyllanthus acidus, phyllanthusols A and B
NCBI PubMed ID: 10993376Publication DOI: 10.1021/jo000439+Journal NLM ID: 2985193RPublisher: Columbus, OH: American Chemical Society
Correspondence: Kittakoop P
Institutions: Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok, Thailand
Methods: 13C NMR, 1H NMR, NMR-2D, FAB-MS, TLC, ESI-MS, HPLC, extraction, CC
Found