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Deng C, Fu H, Xu J, Shang J, Cheng Y
Physiochemical and biological properties of phosphorylated polysaccharides from Dictyophora indusiata
International Journal of Biological Macromolecules 72 (2015)
894-899
Dictyophora indusiata
(NCBI TaxID 146777,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 25316421Publication DOI: 10.1016/j.ijbiomac.2014.09.053Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Deng C <jscdcdjl
163.com>, Cheng Y <chengym2008
126.com>
Institutions: Wuxi Medical School, Jiangnan University, Wuxi, China, School of Pharmaceutics Science, Jiangnan University, Wuxi, China, Wuxi No. 4 people’s Hospital, Wuxi, China
In this study, we aim to investigate the physiochemical and biological properties of water-soluble phosphorylated polysaccharides (P-DIP) obtained from a water-insoluble polysaccharide (DIP) extracted from Dictyophora indusiata. A series of physiochemical properties were determined, including morphology, water-solubility, molecular weight, and degree of substitution (DS). To investigate the antioxidant activity of P-DIP, we determined the scavenging activity of hydroxyl radicals and DPPH, as well as the reducing power. MTT assay was performed to determine the cytotoxic effects of DIP and P-DIP on the cellular proliferation of MCF-7 and B16 cells. Compared with DIP, P-DIP showed a satisfactory water-solubility and significant increase in the antioxidant properties. Moreover, P-DIP also showed more significant inhibitory effects on the growth of MCF-7 and B16 tumor cells than the water-insoluble DIP. These results indicated that phosphorylation might contribute to the improvement of water solubility, as well as antioxidant and anti-tumor activities of natural DIP.
phosphorylation, Dictyophora indusiata, anti-oxidant and anti-tumor activity, dialyisis, centrifugation
Structure type: structural motif or average structure
Location inside paper: p. 894, column 1, paragraph 1, PD3
Trivial name: pachyman, sparan, polycan
Compound class: EPS, cell wall polysaccharide, glucan, polysaccharide
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 13C NMR, IR, GC-MS, GPC, phosphorylation, solubility assays, antioxidant activities, phenol-sulfuric acid assay, antitumor activity assay, MTT, carbazole method, ANOVA, radical scavenging assays
Biological activity: displays antitumor effects on the growth of S180 tumor cells in vivo
Related record ID(s): 42467, 42468
NCBI Taxonomy refs (TaxIDs): 146777Reference(s) to other database(s): GTC:G83138WS
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There is only one chemically distinct structure:
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Deng C, Fu H, Xu J, Shang J, Cheng Y
Physiochemical and biological properties of phosphorylated polysaccharides from Dictyophora indusiata
International Journal of Biological Macromolecules 72 (2015)
894-899
Poria cocos
(later renamed to: Wolfiporia cocos)
(NCBI TaxID 81056,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 25316421Publication DOI: 10.1016/j.ijbiomac.2014.09.053Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Deng C <jscdcdjl
163.com>, Cheng Y <chengym2008
126.com>
Institutions: Wuxi Medical School, Jiangnan University, Wuxi, China, School of Pharmaceutics Science, Jiangnan University, Wuxi, China, Wuxi No. 4 people’s Hospital, Wuxi, China
In this study, we aim to investigate the physiochemical and biological properties of water-soluble phosphorylated polysaccharides (P-DIP) obtained from a water-insoluble polysaccharide (DIP) extracted from Dictyophora indusiata. A series of physiochemical properties were determined, including morphology, water-solubility, molecular weight, and degree of substitution (DS). To investigate the antioxidant activity of P-DIP, we determined the scavenging activity of hydroxyl radicals and DPPH, as well as the reducing power. MTT assay was performed to determine the cytotoxic effects of DIP and P-DIP on the cellular proliferation of MCF-7 and B16 cells. Compared with DIP, P-DIP showed a satisfactory water-solubility and significant increase in the antioxidant properties. Moreover, P-DIP also showed more significant inhibitory effects on the growth of MCF-7 and B16 tumor cells than the water-insoluble DIP. These results indicated that phosphorylation might contribute to the improvement of water solubility, as well as antioxidant and anti-tumor activities of natural DIP.
phosphorylation, Dictyophora indusiata, anti-oxidant and anti-tumor activity, dialyisis, centrifugation
Structure type: homopolymer
Location inside paper: p. 894, column 2, paragraph 1
Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, callose, laminarin, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, cell wall glucan, polysaccharide, glycoside, β-glucan, β-1, 3-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 13C NMR, IR, GC-MS, GPC, phosphorylation, solubility assays, antioxidant activities, phenol-sulfuric acid assay, antitumor activity assay, MTT, carbazole method, ANOVA, radical scavenging assays
Related record ID(s): 42466, 42468
NCBI Taxonomy refs (TaxIDs): 81056Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:
157, CCSD:
50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
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There is only one chemically distinct structure:
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Deng C, Fu H, Xu J, Shang J, Cheng Y
Physiochemical and biological properties of phosphorylated polysaccharides from Dictyophora indusiata
International Journal of Biological Macromolecules 72 (2015)
894-899
Dictyophora indusiata
(NCBI TaxID 146777,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
The structure was elucidated in this paperNCBI PubMed ID: 25316421Publication DOI: 10.1016/j.ijbiomac.2014.09.053Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Deng C <jscdcdjl
163.com>, Cheng Y <chengym2008
126.com>
Institutions: Wuxi Medical School, Jiangnan University, Wuxi, China, School of Pharmaceutics Science, Jiangnan University, Wuxi, China, Wuxi No. 4 people’s Hospital, Wuxi, China
In this study, we aim to investigate the physiochemical and biological properties of water-soluble phosphorylated polysaccharides (P-DIP) obtained from a water-insoluble polysaccharide (DIP) extracted from Dictyophora indusiata. A series of physiochemical properties were determined, including morphology, water-solubility, molecular weight, and degree of substitution (DS). To investigate the antioxidant activity of P-DIP, we determined the scavenging activity of hydroxyl radicals and DPPH, as well as the reducing power. MTT assay was performed to determine the cytotoxic effects of DIP and P-DIP on the cellular proliferation of MCF-7 and B16 cells. Compared with DIP, P-DIP showed a satisfactory water-solubility and significant increase in the antioxidant properties. Moreover, P-DIP also showed more significant inhibitory effects on the growth of MCF-7 and B16 tumor cells than the water-insoluble DIP. These results indicated that phosphorylation might contribute to the improvement of water solubility, as well as antioxidant and anti-tumor activities of natural DIP.
phosphorylation, Dictyophora indusiata, anti-oxidant and anti-tumor activity, dialyisis, centrifugation
Structure type: homopolymer
Location inside paper: Fig. 6(a, b), DIP
Trivial name: D-rhamnan, α-1,3-D-glucan, α-1,3-glucan, (1-3)-α-Glucan, 1-3-α-glucan, α-(1,3)-glucan, α-(1,3)glucan, (1-3)-α-glucan, pseudonigeran, α-(1,3)-glucan, pseudonigeran, water-insoluble α-D-glucan (TM-I)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glucan, polysaccharide, D-glucan
Contained glycoepitopes: IEDB_142488,IEDB_144998,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, IR, GC-MS, GPC, phosphorylation, solubility assays, antioxidant activities, phenol-sulfuric acid assay, antitumor activity assay, MTT, carbazole method, ANOVA, radical scavenging assays
Biological activity: P-DIP has much more salient antioxidant activity, including scavenging activity of hydroxyl radicals and DPPH and reducing power, as well as more significant antitumor activity on B16 tumor cells
Related record ID(s): 42466, 42467
NCBI Taxonomy refs (TaxIDs): 146777Reference(s) to other database(s): GTC:G02177KX, CCSD:
49417, CBank-STR:17683, GenDB:HM245773
Show glycosyltransferases
NMR conditions: in DMSO-d6
[as TSV]
13C NMR data:
Linkage Residue C1 C2 C3 C4 C5 C6
aDGlcp 100.2 71.5 83.4 70.1 72.6 60.8
1H NMR data:
missing...
13C NMR data:
| Linkage | Residue | C1 | C2 | C3 | C4 | C5 | C6 |
|---|
| | aDGlcp | 100.2 | 71.5 | 83.4 | 70.1 | 72.6 | 60.8 |
|
There is only one chemically distinct structure:
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