Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 16528516Publication DOI: 10.1007/s00253-005-0243-zJournal NLM ID: 8406612Publisher: Springer
Correspondence: Song X <songx
sdu.edu.cn>; Qu YB <Quyinbo
sdu.edu.cn>
Institutions: State Key Laboratory of Microbial Technology, Shandong University, Jinan, China, Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China
The effects of sophorolipid on the growth and apoptosis of H7402 human liver cancer cells were investigated. By treatment with sophorolipid, a dose- and time-dependent inhibition of cell proliferation was observed. The cells developed many features of apoptosis, including condensation of chromatin, nuclear fragmentation, and appearance of apoptotic bodies, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling positive cells were stained dark brown. Sophorolipid treatment induced apoptosis in H7402 cells by blocking cell cycle at G1 phase and partly at S phase, activating caspase-3, and increasing Ca2+ concentration in cytoplasm. These findings may suggest a potential use of sophorolipid for liver cancer treatment.
apoptosis, anti-cancer, sophorolipid, Wickerhamiella domercqiae
Structure type: cyclic polymer repeating unit
Location inside paper: Fig. 1
Compound class: glycolipid, sophorolipid
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: cell growth, enzymatic assay, fluorescence binding assay, cell viability assay, TEM, MTT, TUNEL assay
Biological activity: sophorolipid induces apoptosis in H7402 human liver cancer cells and causes a dramatic increase in G1 phase and partly in S phase distribution of H7402 cancer cells
NCBI Taxonomy refs (TaxIDs): 45788
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error