Guo S, Mao W, Yan M, Zhao C, Li N, Shan J, Lin C, Liu X, Guo T, Wang S Galactomannan with novel structure produced by the coral endophytic fungus Aspergillus ochraceus Carbohydrate Polymers105 (2014)
325–333
The structure was elucidated in this paper NCBI PubMed ID:24708987 Publication DOI:10.1016/j.carbpol.2014.01.079 Journal NLM ID:8307156 Publisher: Elsevier Correspondence: Mao W <wenjunmqdhotmail.com> Institutions: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China, Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian, Shandong, China
The homogeneous extracellular polysaccharide, AW1, was obtained from the fermented broth of the fungus Aspergillus ochraceus derived from coral Dichotella gemmacea. AW1 was a galactomannan with a molar ratio of mannose and galactose of 2.16:1.00 and a molecular weight of about 29.0kDa. The structure of AW1 was investigated by chemical and spectroscopic methods, including methylation analysis, one- and two-dimensional nuclear magnetic resonance (1D, 2D NMR) and electrospray mass spectrometry with collision-induced dissociation (ES-CID MS/MS) spectroscopic analyses. The results showed that the backbone of AW1 consisted of (1⟶2)-linked α-d-mannopyranose residues. The mannopyranose residues in the backbone were substituted at C-6 by the (1⟶)-linked α-d-mannopyranose units and (1⟶5)-linked β-D-galactofuranose oligosaccharides with different degrees of polymerization. The investigation demonstrated that AW1 was a novel galactomannan with different structural characteristics from other fungal galactomannans, and could be a potential resource of the (1⟶5)-linked β-D-galactofuranose oligosaccharides.
Guo S, Mao W, Yan M, Zhao C, Li N, Shan J, Lin C, Liu X, Guo T, Wang S Galactomannan with novel structure produced by the coral endophytic fungus Aspergillus ochraceus Carbohydrate Polymers105 (2014)
325–333
The structure was elucidated in this paper NCBI PubMed ID:24708987 Publication DOI:10.1016/j.carbpol.2014.01.079 Journal NLM ID:8307156 Publisher: Elsevier Correspondence: Mao W <wenjunmqdhotmail.com> Institutions: Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China, Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taian, Shandong, China
The homogeneous extracellular polysaccharide, AW1, was obtained from the fermented broth of the fungus Aspergillus ochraceus derived from coral Dichotella gemmacea. AW1 was a galactomannan with a molar ratio of mannose and galactose of 2.16:1.00 and a molecular weight of about 29.0kDa. The structure of AW1 was investigated by chemical and spectroscopic methods, including methylation analysis, one- and two-dimensional nuclear magnetic resonance (1D, 2D NMR) and electrospray mass spectrometry with collision-induced dissociation (ES-CID MS/MS) spectroscopic analyses. The results showed that the backbone of AW1 consisted of (1⟶2)-linked α-d-mannopyranose residues. The mannopyranose residues in the backbone were substituted at C-6 by the (1⟶)-linked α-d-mannopyranose units and (1⟶5)-linked β-D-galactofuranose oligosaccharides with different degrees of polymerization. The investigation demonstrated that AW1 was a novel galactomannan with different structural characteristics from other fungal galactomannans, and could be a potential resource of the (1⟶5)-linked β-D-galactofuranose oligosaccharides.
Fernández T, Wagner ML, Varela BG, Ricco RA, Hajos SE, Gurni AA, Alvarez E Study of an Argentine mistletoe, the hemiparasite Ligaria cuneifolia (R. et P.) Tiegh. (Loranthaceae) Journal of Ethnopharmacology62(1) (1998)
25-34
/Variants 0/-Quercetin
/Variants 0/ is:
b-D-Xylp-(1-3)-
OR (exclusively)
a-L-Rhap-(1-3)-
OR (exclusively)
a-L-Arap-(1-3)-
Taxonomic group: plant / Streptophyta (Phylum: Streptophyta) Organ / tissue:root
The structure was elucidated in this paper NCBI PubMed ID:9720608 Publication DOI:10.1016/s0378-8741(98)00030-0 Journal NLM ID:7903310 Publisher: Limerick: Elsevier Sequoia Institutions: Cátedra de Inmunología-IDEHU, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Cátedra de Farmacobotánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Museo de Farmacobotánica ‘Juan A. Domı´nguez’, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Research Career, CONICET, Facultad de Farmacia y Bioquímica, Uni6ersidad de Buenos Aires, Buenos Aires, Argentina
Ligaria cuneifolia (R. et P.) Tiegh, is an hemiparasite species used in Argentine folk medicine as a substitute for the European mistletoe (Viscum album L.) based on its putative activity of decreasing high blood pressure. This paper analyzes flavonoid composition, protein constituents and the possible immunomodulatory and antitumoral effects of this species. Micromolecular study disclosed quercetin-free, quercetin-glycosylated and proanthocyanidins corresponding to cyanidin monomers, which implies a particular metabolic pathway. Proteins present in L. cuneifolia extracts analyzed by SDS-PAGE presented multiple bands with molecular weights ranging from 14 to 90 kD. These features contribute to the characterization of the native mistletoe. As V. album is being used in cancer treatment due to its immunomodulatory and antitumoral activity, the action of aqueous L. cuneifolia extracts on murine lymphocytes was investigated. Culture of murine spleen cells alone or stimulated with Concanavalin A or lipopolysaccharide in presence of L. cuneifolia extracts indicated a certain stimulation of splenocytes alone and an inhibition of splenocytes stimulated with Concanvalin A or lipopolysaccharide. An inhibitory effect was also observed on the proliferation of murine leukemia cells. In addition, aqueous extracts increased nitric oxide production by murine macrophages. These results suggest that L. cuneifolia extracts exert an immunomodulatory effect on the mouse immune system.
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