Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 29874078Publication DOI: 10.1021/acs.jpcb.8b03081Journal NLM ID: 101157530Publisher: Washington, DC: American Chemical Society
Correspondence: Mehta SK <skmehta
pu.ac.in>; Gradzielski M <michael.gradzielski
tu-berlin.de>
Institutions: Department of Chemistry and Centre for Advanced Studies in Chemistry, Panjab University, Chandigarh, India, Stranski Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Berlin, Germany
The objective of the present work was to develop solid lipid nanoparticles (SLNs) as drug-encapsulating structures by the solvent injection method. In this report, for the first time the inherent potential of lactonic sophorolipid (glycolipid) was exploited to formulate SLNs. A range of different Pluronic copolymers were screened by dynamic and static light scattering with the aim of obtaining most stable SLNs. To comprehend the structure of the SLNs, techniques such as transmission electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray diffraction were employed. A clear correlation between the type of Pluronic and size and stability of the SLNs could be drawn. The vector properties of the formed SLNs were assessed for both the encapsulated hydrophobic drugs-rifampicin and dapsone. To elucidate the transport mechanism of drug release, kinetic modeling was carried out on the drug release profiles. The promising results of sophorolipid-based SLNs have actually established a new arena beneath the significantly developed field of SLNs.
X-ray, TEM, nanoparticles, drug delivery systems
Structure type: cyclic polymer repeating unit ; n=1
C
17H
24O
14Location inside paper: Fig. 1
Trivial name: lactone sophorolipid, sophorolipid
Compound class: glycolipid, sophorolipid
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: X-ray, FTIR, dialysis, dynamic light scattering, TEM, static light scattering, differential scanning calorimetry
Comments, role: used in the formation of solid lipid nanoparticles
Related record ID(s): 48566, 48623, 48735, 48736, 48797, 48829, 48830, 48831, 48832, 48834, 48835, 48836, 48837, 48838, 48839, 48840, 48841, 48842, 48843, 48844, 48845, 48846, 48847, 48848, 48849, 48850, 48851, 48852, 48977, 48985, 48986, 48990
NCBI Taxonomy refs (TaxIDs): 75736
Show glycosyltransferases
There is only one chemically distinct structure:
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