Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Publication DOI: 10.1080/09540105.2020.1713055Journal NLM ID: 8918113Publisher: Hopkinton Ma: Carfax Publishing
Correspondence: Tang C-H <chtang
mail.cmu.edu.tw>; Li T-M <leedemaw
mail.cmu.edu.tw>
Institutions: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, School of Chinese Medicine, China Medical University, Taichung, Taiwan, Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan, Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan, Chinese Medicine Research Center, China Medical University, Taichung, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan, China Medical University Children’s Hospital, China Medical University, Taichung, Taiwan, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pathological states. Soya-cerebroside, an extract from Cordyceps militaris, reduces synovial inflammation and prevents cartilage damage in an osteoarthritis model. However, the role of soya-cerebroside in VEGF-regulated EPC angiogenesis is uncertain. Records from the Oncomine database demonstrate higher levels of VEGF in cancerous tissue compared with normal tissue. This study describes VEGF-induced promotion of EPC-associated angiogenesis in vivo and how the treatment of EPCs with soya-cerebroside inhibited VEGF-facilitated migration and tube formation. The study evidence shows that the c-Src, FAK and Runx2 signalling pathways are involved in the inhibitory effects of soya-cerebroside. This novel agent may therefore be used to inhibit EPC-associated angiogenesis.
angiogenesis, soya-cerebroside, endothelial progenitor cells, VEGF
Structure type: monomer
Location inside paper: abstract
Trivial name: soya-cerebroside I, soya-cerebroside
Compound class: glycolipid, cerebroside
Contained glycoepitopes: IEDB_137339,IEDB_142488,IEDB_146664,IEDB_983931,SB_192,SB_5
Methods: Western blotting, biological assays, cell growth, gene expression, immunohistochemistry, angiogenesis assay
Biological activity: soya-cerebroside inhibits VEGF-induced promotion of EPC angiogenesis involving c-Src, FAK and Runx2
Related record ID(s): 50148, 51033, 51040, 51041
NCBI Taxonomy refs (TaxIDs): 73501
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There is only one chemically distinct structure:
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