Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting bodies
NCBI PubMed ID: 35725184Publication DOI: 10.1016/j.carbpol.2022.119698Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: S. Tang <tshunqt
jnu.edu.cn>
Institutions: Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China, School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, China
Host reactions following implantation of biomaterials, especially the macrophages' responses could significantly affect the wound healing process. Therefore, it is meaningful to develop immunostimulatory active wound dressing to accelerate wound healing. In this study, lentinan (LNT) was esterified with different carboxylic acids, and the bilayer nanofibrous membrane (BilayerM) based on the esterified LNT was designed. BilayerM exhibited good water absorption, red blood cells (RBC), platelets, and fibronectin adhesion abilities. The ELISA results indicated that BilayerM stimulated macrophages to secrete pro-inflammatory and pro-regenerative cytokines. Moreover, cell migration results showed that BilayerM promoted the migration and proliferation of NIH3T3 and HUVECs. The wound healing efficacy studies demonstrated that BilayerM significantly accelerated the wound healing rate in a full-thickness skin defect model. Therefore, these results indicate that this bioactive dressing is a hopeful candidate for clinical treatment of cutaneous wounds.
wound healing, bilayer nanofibrous membrane, esterified lentinan
Structure type: polymer chemical repeating unit ; 2910000
Location inside paper: scheme 1, LNT
Trivial name: lentinan (LNT)
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 1H NMR, ELISA, FTIR, statistical analysis, cytokine assay, cytotoxicity assay, SEM, TGA, XRD, esterification, electrospinning technology, hemostasis assay
NCBI Taxonomy refs (TaxIDs): 5353
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Lentinula edodes)