Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Host organism: Alcyonacea
NCBI PubMed ID: 35194907Publication DOI: 10.1002/cbdv.202100925Journal NLM ID: 101197449Publisher: Verlag Helvetica Chimica Acta
Correspondence: B. Yang <yangbin
scsio.ac.cn>; Y. Liu <yonghongliu
scsio.ac.cn>
Institutions: CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, P. R. China, University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, P. R. China, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, P. R. China
Two new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide-inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti-acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC50 value of 157.8 μM.
nitric oxide, Aspergillus, acetylcholinesterase inhibitory, soft coral
Structure type: monomer
Location inside paper: fig. 1, compound 15
Trivial name: chrysogeside E
Compound class: glucosylceramide
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, IR, TLC, HPLC, UV, extraction, optical rotation measurement, fermentation, HR-ESI-MS, determination of NO production, ECD, kinase inhibition assay
NCBI Taxonomy refs (TaxIDs): 5052
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error