Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: whole plant
Publication DOI: 10.1080/00387019909350045Journal NLM ID: 1276432Publisher: New York, NY: Marcel Dekker
Institutions: National Laboratory of Pharmaceutical Biotechnology, Department of Biological Science and Technology, Nanjing University, Nanjing, 210093, China, National Laboratory of Applied, Organic Chemistry at Lanzhou University, Lanzhou, 730000, China
In addition to the plant sterols β-sitosterol and daucosterol, a new bisabolane-typed sesquiterpene glycoside and three bioactive compounds (artemetin, geniposide and 6β-hydroxygeniposide) were characterized from the whole plant of Biebersteinia heterostemon endemic to the Tibetan area. The structure determination of the novel glycoside and identification of the known phytochemicals were accomplished by a combination of modern spectroscopic methods. Tests of all isolates for the antimicrobial activity indicated that the new sesquiterpene glycoside exhibited pronounced antibacterial activities against Bacillus subtilis, Staphylococcus aureus and Pseudomonas sp. with MICs at 50, 50 and 70 μg/ml, respectively.
antibacterial activity, Geraniaceae, Iridoids, Biebersteinia heterostemon, monoterpenes, (-)-anymol glycoside
Structure type: monomer
Location inside paper: daucosterol, p. 1009 (daucosterol)
Trivial name: daucosterol, β-daucosterol, β-sitosterol, β-sitosterol-β-D-glucoside, androsine, saxifragifolin B, β-sitosterol 3-O-β-D-glucopyranoside
Compound class: saponin glycoside, glycoside, steroid glycoside, triterpene glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, MS, optical rotation measurement, HMBC, HMQC, DEPT, antimicrobial assay, COSY, NOESY
Comments, role: stucture of daucosterol was elucidated with help of comparative spectral data
Related record ID(s): 62503, 62505, 62506
NCBI Taxonomy refs (TaxIDs): 375289Reference(s) to other database(s): GenDB:MK026953.1
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There is only one chemically distinct structure:
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