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Taxonomic group: plant / Streptophyta (Phylum: Streptophyta)
Organ / tissue: fruit

Publication DOI: 10.1076/phbi.37.1.42.6325
Journal NLM ID: 9812552
Publisher: Lisse, the Netherlands: Swets & Zeitlinger
Institutions: Faculty of Science, Prince of Songkla University, Hat Yai, Thailand, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Thailand, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario, Canada

Ursolic acid (1), pseudoginsenoside RP1 (2), and psuedoginsenoside RT1 (3) were isolated from the fruit of Randia siamensis. 13C NMR spectroscopy was particularly useful in confirming the structures of these components. Studies with rats showed that saponin 3 caused a decrease in blood pressure, an increase in heart rate and an increase in spontaneous contractility of the uterus. Also, a crude ethanol extract of the fruit of R. siamensis exhibited acute ichthyotoxic activity.

saponins, pseudoginsenoside RT1, cardiovascular activity, ichthyotoxic activity, Randia siamensis, uterine contractility

Structure type: oligomer
Location inside paper: pseudoginsenoside RP1, compound 2
Trivial name: pseudoginsenoside RP1
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_140630,IEDB_167188,IEDB_174332,IEDB_423153

Methods: 13C NMR, FAB-MS, TLC, cardiovascular activity, uterine contractility
Comments, role: compound was identified based on published data, see ref. [Tanaka et al., 1985]

Related record ID(s): 63041
NCBI Taxonomy refs (TaxIDs): 58445
Show glycosyltransferases

There is only one chemically distinct structure:

CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]6O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1

SVG MW SMILES 3D mol Ionize

saponins, pseudoginsenoside RT1, cardiovascular activity, ichthyotoxic activity, Randia siamensis, uterine contractility

Structure type: oligomer ; 925 [M-H]-
Location inside paper: pseudoginsenoside RT1, compound 3
Trivial name: pseudoginsenoside RT1
Compound class: saponin glycoside
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_140630,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_423153,IEDB_983931,SB_192

Methods: 13C NMR, FAB-MS, TLC, cardiovascular activity, uterine contractility
Biological activity: Pseudoginsenoside RT1 caused a decrease in blood pressure, an increase in heart rate and an increase in spontaneous contractility of the uterus in rats.
Comments, role: compound was identified based on published data, see ref. [Tanaka et al., 1985]

Related record ID(s): 63040
NCBI Taxonomy refs (TaxIDs): 58445
Show glycosyltransferases

There is only one chemically distinct structure:

CC1(C)CC[C@]2(C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]6O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1

SVG MW SMILES 3D mol Ionize