Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 10913616Publication DOI: 10.1016/s0014-5793(00)01730-0Journal NLM ID: 0155157Publisher: Elsevier
Correspondence: Kanazawa K <kazuki
kobe-u.ac.jp>
Institutions: Laboratory of Food and Nutritional Chemistry, Faculty of Agriculture, Kobe University, Kobe, Japan
Dioxins invade the body mainly through the diet, and produce toxicity through the transformation of aryl hydrocarbon receptor (AhR). An inhibitor of the transformation should therefore protect against the toxicity and ideally be part of the diet. We examined flavonoids ubiquitously expressed in plant foods as one of the best candidates, and found that the subclasses flavones and flavonols suppressed antagonistically the transformation of AhR induced by 1 nM of 2,3,7,8-tetrachlorodibenzo-p-dioxin, without exhibiting agonistic effects that transform AhR. The antagonistic IC(50) values ranged from 0.14 to 10 μM, close to the physiological levels in human.
flavonoid, cancer prevention, dioxin antagonist, aryl hydrocarbon receptor, transformation inhibitor, dietary phytochemical
Structure type: oligomer
C
27H
30O
16Location inside paper: p. 215, Table 1
Trivial name: rutin, rutoside, rutin, quercetin rutinoside, rutoside, quercetin 3-O-rutinose, quercetin-3-O-rutinoside, quercetin 3-O-rutinoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: DNA techniques, biological assays, radiolabeling, centrifugation, autoradiography
Related record ID(s): 64751, 64752, 64754, 64755
NCBI Taxonomy refs (TaxIDs): 35493Reference(s) to other database(s): CCSD:
50720, CBank-STR:3399
Show glycosyltransferases
There is only one chemically distinct structure:
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