Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 7553983Publication DOI: 10.1248/cpb.43.1385Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy Research Laboratories of Biological Science, Kodama Limited Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Two simple coumarins, scoparone (1) and scopoletin (2), and three flavonoids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract. Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen. Capillarisin (21) exhibits a potent inhibitory effect on bovine-LAR. In addition, thirteen simple coumarins, five coumarin glycosides and two flavonoids were tested for their inhibitory effect against bovine-LAR and rabbit platelet aggregation.
flavonoid, diabetic complication, platelet aggregation, coumarin, Artemisiae Capillari Spica, bovine lens aldose reductase
Structure type: monomer
C
21H
20O
11Location inside paper: p. 1386, Chart 1, structure 25
Trivial name: quercitrin, baohuoside-II, quercetin 3-rhamnoside, quercetin 3-O-rhamnoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823
Methods: inhibition studies, biological assays, extraction
Related record ID(s): 67212, 67213, 67214, 67215
NCBI Taxonomy refs (TaxIDs): 265783Reference(s) to other database(s): CCSD:
49971, CBank-STR:599
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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