Found 29 structures.
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1. Compound ID: 10989
Structure type: polymer chemical repeating unit
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 4451
Naumova IB, Shashkov AS "Anionic polymers in cell walls of Gram-positive bacteria" -
Biochemistry (Moscow) 62(8) (1997) 809-840
Information on the prevalence, compositions, and structures of anionic carbohydrate-containing polymers of cell walls of Gram-positive bacteria is summarized. The data suggest that these polymers are important for normal functioning of bacterial cells and require further studies. Structural data on teichoic acids found in the literature published over the last few years are discussed. This is a very diverse class of polymers whose structure-specific pathways of degradation were studied and NMR spectra were examined. Unique comprehensive tables of 13C-NMR spectroscopic data (mainly obtained by the authors) on these polymers are given in the Appendix. Other tables summarize data on teichuronic acids, sugar-phosphate polymers, acid polysaccharides, and structural variants of bonds between acid polysaccharides and peptidoglycans known from the literature. Functions of anionic polymers and their possible chemotaxonomic applications are discussed
13C-NMR, NMR, structure, cell wall, composition, teichoic acid, teichuronic acid, Gram-positive, gram-positive bacteria, taxonomy
NCBI PubMed ID: 9360295Journal NLM ID: 0376536Publisher: Nauka/Interperiodica
Institutions: School of Biology, Lomonosov Moscow State University, Russia
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2. Compound ID: 11019
Structure type: homopolymer
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705
The structure is contained in the following publication(s):
- Article ID: 4452
Naumova IB, Shashkov AS, Tul'skaya EM, Streshinskaya GM, Kozlova YI, Potekhina NV, Evtushenko LI, Stackebrandt E "Cell wall teichoic acids: structural diversity, species specificity in the genus Nocardiopsis, and chemotaxonomic perspective" -
FEMS Microbiology Reviews 25(3) (2001) 269-283
Data on the structures of cell wall teichoic acids, the anionic carbohydrate-containing polymers, found in many Gram-positive bacteria have been summarized and the polymers of the actinomycete genus Nocardiopsis have been considered from the taxonomic standpoint. The structures of these polymers or their combinations have been demonstrated to be indicative of each of seven Nocardiopsis species and two subspecies, verified by the DNA-DNA relatedness data, and to correlate well with the grouping of the organisms based on 16S rDNA sequences. As each of the intrageneric taxa discussed is definable by the composition of teichoic acids, the polymers are considered to be valuable taxonomic markers for the Nocardiopsis species and subspecies. The (13)C NMR spectra of the polymers, data on the products of their chemical degradation, and distinguishing constituents of whole cell walls derived from teichoic acids are discussed, which are useful for identification of certain polymers and members of the genus Nocardiopsis at the species and subspecies level in microbiological practice.
Nocardiopsis, teichoic acid, taxonomy, actinomycetes
NCBI PubMed ID: 11348685Journal NLM ID: 8902526Publisher: Oxford University Press
Correspondence: naumova@l.micro.bio.msu.ru
Institutions: School of Biology, Lomonosov Moscow State University, Moscow 119899
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3. Compound ID: 11029
Structure type: polymer chemical repeating unit
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 4456
Potekhina NV, Evtushenko LI, Senchenkova SN, Shashkov AS, Naumova IB "Structures of cell wall teichoic acids of Brevibacterium iodinum VKM Ac-2106T" -
Biochemistry (Moscow) 69(12) (2004) 1353-1359
The structures of two cell wall teichoic acids of Brevibacterium iodinum VKM Ac-2106(T) were studied. The structure of mannitol teichoic acid described earlier was mainly confirmed. This polymer is 1,6-poly(mannitol phosphate) bearing β-D-glucopyranosyl residues at the C-2 of mannitol and pyruvic acid residues at the C-4 and C-5. The absolute configurations of D-mannitol and S-pyruvic acid were found. The following distinctions from the earlier described structure were found: unsubstituted 1,6-poly(mannitol phosphate) residues and residues substituted only by β-D-glucopyranosyl at the C-2 of mannitol but unsubstituted by pyruvic acid are present in the chain. The structure of glycerol teichoic acid present in the cell wall as a minor component (~7%) is also described. This acid is identified as 1,3-poly(glycerol phosphate) substituted at the C-2 of glycerol by 2-acetamido-2-deoxy-α-D-galactopyranosyl residues bearing R-pyruvic acid residues at the C-4 and C-6 of galactose. This polymer is for the first time described in the cell wall of Gram-positive bacteria.
teichoic acids, Brevibacterium, poly(glycerol phosphate), Pyruvic acid acetal, NMR-spectroscopy, poly(mannitol phosphate)
NCBI PubMed ID: 15627390Journal NLM ID: 0376536Publisher: Nauka/Interperiodica
Correspondence: potekchina@hotbox.ru
Institutions: Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia
Methods: 13C NMR, 1H NMR, HF solvolysis, sugar analysis, acid hydrolysis, paper chromatography, paper electrophoresis, 32P NMR
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4. Compound ID: 11054
Structure type: homopolymer
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705
The structure is contained in the following publication(s):
- Article ID: 4464
Shashkov AS, Potekhina NV, Evtushenko LI, Naumova IB "Cell wall teichoic acids of two Brevibacterium strains" -
Biochemistry (Moscow) 69(6) (2004) 658-664
Structurally identical teichoic acids were detected in cell walls of two soil isolates assigned to Brevibacterium linens based on phylogenetic data. Both cell walls contain unsubstituted 1,3-poly(glycerol phosphate) and poly(glycosylglycerol phosphate). Repeating units of the latter →α-D-GlcpNAc-(1→4)-β-D-Galp-(1→1)-Gro→ are bound by phosphodiester bonds including OH-3 of galactose and OH-3 of glycerol. Some of the N-acetylglucosamine residues have 4,6-pyruvic acid acetal, amounts of the latter in the two strains being unequal. Species-specificity of the structures of teichoic acids in the genus Brevibacterium is discussed.
teichoic acid, Brevibacterium, poly(glycosylglycerol phosphate), Pyruvic acid acetal
NCBI PubMed ID: 15236605Journal NLM ID: 0376536Publisher: Nauka/Interperiodica
Correspondence: potekhina@hotbox.ru
Institutions: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
Methods: 13C NMR, 1H NMR, HF solvolysis, sugar analysis, 31P NMR, acid hydrolysis, paper chromatography, alkaline hydrolysis, paper electrophoresis
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5. Compound ID: 11328
|
-3)-b-D-Galp-(1-3)-b-D-Galf5Ac6Ac-(1-3)-b-D-Glcp-(1-6)-b-D-Galf2Ac-(1-1)-Man-ol-(6-P- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 4566
Lin FL, Vinogradov E, Deng C, Zeller S, Green BA, Jansen KU, Pavliak V "Identification of the common antigenic determinant shared by Streptococcus pneumoniae serotypes 33A, 35A, and 20 capsular polysaccharides" -
Carbohydrate Research 380 (2013) 101-107
In order to better understand cross-reactions of serogroup 33 polysaccharides and the typing sera, the structure of pneumococcal capsular polysaccharide serotype 33A was elucidated. Serotype 33A has been shown to have an identical polysaccharide backbone as that of serotype 33F, with two additional sites of O-acetylation at C5, and C6 of the 3-β-Galf residue in serotype 33A. This finding is consistent with the presence of an additional functional acetyltransferase gene (wcjE) in the cps biosynthetic locus of serotype 33A compared to 33F. The identical polysaccharide backbone with at least one common O-acetylation site (C2 of 5-β-Galf) shared by serotype 33A and 33F polysaccharides is proposed to be the epitope recognized by typing serum 33b. In addition, a 5,6-di-O-acetylated →3)-β-D-Galf5,6Ac-(1→3)-β-D-Glcp-(1→ disaccharide unit, a common structural motif present in serotypes 33A, 20, and 35A polysaccharides, is proposed to be the antigenic determinant recognized by typing serum 20b.
Streptococcus pneumoniae, antigenic determinant, capsular polysaccharide structure, acetyltransferase, Serotype 33A
NCBI PubMed ID: 23981856Publication DOI: 10.1016/j.carres.2013.08.001Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: fiona.lin@pfizer.com
Institutions: Pfizer Vaccine Research, 401 N. Middletown Road, Pearl River, NY 10965, USA
Methods: 13C NMR, 1H NMR, NMR-2D, GC-MS, sugar analysis, acid hydrolysis, MS/MS, de-O-acetylation, NMR-1D, HPAEC-PAD, CE-MS
- Article ID: 4828
Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C, Konradsen HB, Nahm MH "Pneumococcal Capsules and Their Types: Past, Present, and Future" -
Clinical Microbiology Reviews 28(3) (2015) 871-899
Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its virulence is largely due to its polysaccharide capsule, which shields it from the host immune system, and because of this, the capsule has been extensively studied. Studies of the capsule led to the identification of DNA as the genetic material, identification of many different capsular serotypes, and identification of the serotype-specific nature of protection by adaptive immunity. Recent studies have led to the determination of capsular polysaccharide structures for many serotypes using advanced analytical technologies, complete elucidation of genetic basis for the capsular types, and the development of highly effective pneumococcal conjugate vaccines. Conjugate vaccine use has altered the serotype distribution by either serotype replacement or switching, and this has increased the need to serotype pneumococci. Due to great advances in molecular technologies and our understanding of the pneumococcal genome, molecular approaches have become powerful tools to predict pneumococcal serotypes. In addition, more-precise and -efficient serotyping methods that directly detect polysaccharide structures are emerging. These improvements in our capabilities will greatly enhance future investigations of pneumococcal epidemiology and diseases and the biology of colonization and innate immunity to pneumococcal capsules.
serotype, Streptococcus pneumoniae, vaccines, Pneumococcal Capsules
NCBI PubMed ID: 26085553Publication DOI: 10.1128/CMR.00024-15Journal NLM ID: 8807282Publisher: Washington, DC: American Society for Microbiology
Correspondence: Moon H. Nahm
Institutions: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA, Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology & Medical Research, Westmead Hospital, Wentworthville, New South Wales, Australia, Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, New South Wales, Australia, Division of Infectious Disease, Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea, SSI Diagnostica, Division of Microbiology and Diagnostics, Statens Serum Institut, Copenhagen, Denmark, Pneumonia Program Strategy Team, Bill & Melinda Gates Foundation, Seattle, Washington, USA, Laboratory for Molecular Structure, NIBSC, South Mimms, Herts, United Kingdom, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
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6. Compound ID: 12133
|
a-D-Glcp-(1-2)-+
|
-6)-b-D-Galf-(1-1)-Man-ol-(6--P--3)--b-D-Galp-(1-3)-b-D-Galf-(1-3)-b-D-Glcp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_153217,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 4828
Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C, Konradsen HB, Nahm MH "Pneumococcal Capsules and Their Types: Past, Present, and Future" -
Clinical Microbiology Reviews 28(3) (2015) 871-899
Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its virulence is largely due to its polysaccharide capsule, which shields it from the host immune system, and because of this, the capsule has been extensively studied. Studies of the capsule led to the identification of DNA as the genetic material, identification of many different capsular serotypes, and identification of the serotype-specific nature of protection by adaptive immunity. Recent studies have led to the determination of capsular polysaccharide structures for many serotypes using advanced analytical technologies, complete elucidation of genetic basis for the capsular types, and the development of highly effective pneumococcal conjugate vaccines. Conjugate vaccine use has altered the serotype distribution by either serotype replacement or switching, and this has increased the need to serotype pneumococci. Due to great advances in molecular technologies and our understanding of the pneumococcal genome, molecular approaches have become powerful tools to predict pneumococcal serotypes. In addition, more-precise and -efficient serotyping methods that directly detect polysaccharide structures are emerging. These improvements in our capabilities will greatly enhance future investigations of pneumococcal epidemiology and diseases and the biology of colonization and innate immunity to pneumococcal capsules.
serotype, Streptococcus pneumoniae, vaccines, Pneumococcal Capsules
NCBI PubMed ID: 26085553Publication DOI: 10.1128/CMR.00024-15Journal NLM ID: 8807282Publisher: Washington, DC: American Society for Microbiology
Correspondence: Moon H. Nahm
Institutions: Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA, Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology & Medical Research, Westmead Hospital, Wentworthville, New South Wales, Australia, Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, New South Wales, Australia, Division of Infectious Disease, Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea, SSI Diagnostica, Division of Microbiology and Diagnostics, Statens Serum Institut, Copenhagen, Denmark, Pneumonia Program Strategy Team, Bill & Melinda Gates Foundation, Seattle, Washington, USA, Laboratory for Molecular Structure, NIBSC, South Mimms, Herts, United Kingdom, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
- Article ID: 5791
Knirel YA, Van Calsteren M "Bacterial exopolysaccharides" -
Book: Comprehensive Glycoscience: From Chemistry to Systems Biology. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (2021) 1-75
Bacterial extracellular polysaccharides are known as a cell-bound capsule, a sheath, or a slime, which is excreted into the environment. They play an important role in virulence of medical bacteria and plant-to-symbiont interaction and are used for serotyping of bacteria and production of vaccines. Some exopolysaccharides have commercial applications in industry, and claims of health benefits have been documented for an increasing number of them. Exopolysaccharides have diverse composition and structure, and some contain sugar and non-sugar components that are found in bacterial carbohydrates only. The present article provides an updated collection of the data on exopolysaccharides of various classes of gram-negative and gram-positive bacteria reported until the end of 2019. When known, biosynthesis pathways of exopolysaccharides are treated in a summary manner. References are made to structure and biosynthesis relatedness between exopolysaccharides of different bacterial taxa as well as between bacterial polysaccharides and mammalian glycosaminoglycans.
polysaccharide structure, Gram-negative bacteria, capsule, Biofilm, polysaccharide biosynthesis, gram-positive bacteria, Monosaccharide composition, Bacterial exopolysaccharide, non-sugar component
Publication DOI: 10.1016/B978-0-12-819475-1.00005-5Publisher: Elsevier
Correspondence: marie-rose.vancalsteren@canada.ca; yknirel@gmail.com
Editors: Barchi J, Kamerling H
Institutions: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, Saint-Hyacinthe Research and Development Centre, Agriculture and Agri-Food Canada, Saint-Hyacinthe, QC, Canada
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7. Compound ID: 14026
|
a-D-Glcp-(1-2)-+
|
-6)-b-D-Galf2Ac-(1-1)-Man-ol-(6--P--3)--b-D-Galp-(1-3)-b-D-Galf5Ac6Ac-(1-3)-b-D-Glcp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_153217,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 5537
Geno KA, Bush CA, Wang M, Jin C, Nahm MH, Yang J "Structure and function of the branched receptor-binding complex of bacteriophage CBA120" -
Journal of Clinical Microbiology 55(9) (2017) 2775-2784
Streptococcus pneumoniae expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types, are in a chromosomal region known as the cps locus. The nucleotide sequence in this region has been determined for all serotypes. In contrast, not all CPS structures have been defined. The structure of the serotype 35C polysaccharide was recently reported, but the presence of O-acetyltransferase genes in the serotype 35C cps locus suggested that it could be incomplete, as the reported structure contains no O-acetylation. In addition, the genetic distinction of serotype 35C from the closely related serotype 42 was unclear, as their reported cps loci are nearly identical. To clarify these discrepancies, we obtained serotype 35C and 42 clinical and reference isolates and studied their serological and genetic properties, as well as the structures of CPSs purified from reference isolates. We demonstrated that the O-acetyltransferase WciG was functional in serotype 35C but nonfunctional in serotype 42 due to a deletion in wciG Serotype 35C was O-acetylated at the 5- and 6-positions of 3-β-galactofuranose, as well as the 2-position of 6-β-galactofuranose. However, serotype 42 has only O-acetylation at 3-β-galactofuranose, an observation consistent with its loss of WciG functionality, which is associated with O-acetylation at the 2-position and subsequent reaction with typing antiserum 35a. These findings provide a comprehensive view of the genetic, biochemical structural, and serological bases of serotypes 35C and 42.
Streptococcus pneumoniae, capsular polysaccharide, serotyping, O-acetyltransferase, biochemical structure, genetic basis, serological profile
NCBI PubMed ID: 28659323Publication DOI: 10.1128/JCM.00822-17Journal NLM ID: 7505564Publisher: American Society for Microbiology
Correspondence: Moon H. Nahm
; Jinghua Yang
Institutions: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Methods: 13C NMR, 1H NMR, NMR-2D, DNA sequencing, DNA techniques, ELISA, biochemical methods, SEC, flow cytometric serotyping assays
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8. Compound ID: 14027
|
a-D-Glcp-(1-2)-+
|
-6)-b-D-Galf-(1-1)-Man-ol-(6--P--3)--b-D-Galp-(1-3)-b-D-Galf5Ac6Ac-(1-3)-b-D-Glcp-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_153217,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 5537
Geno KA, Bush CA, Wang M, Jin C, Nahm MH, Yang J "Structure and function of the branched receptor-binding complex of bacteriophage CBA120" -
Journal of Clinical Microbiology 55(9) (2017) 2775-2784
Streptococcus pneumoniae expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types, are in a chromosomal region known as the cps locus. The nucleotide sequence in this region has been determined for all serotypes. In contrast, not all CPS structures have been defined. The structure of the serotype 35C polysaccharide was recently reported, but the presence of O-acetyltransferase genes in the serotype 35C cps locus suggested that it could be incomplete, as the reported structure contains no O-acetylation. In addition, the genetic distinction of serotype 35C from the closely related serotype 42 was unclear, as their reported cps loci are nearly identical. To clarify these discrepancies, we obtained serotype 35C and 42 clinical and reference isolates and studied their serological and genetic properties, as well as the structures of CPSs purified from reference isolates. We demonstrated that the O-acetyltransferase WciG was functional in serotype 35C but nonfunctional in serotype 42 due to a deletion in wciG Serotype 35C was O-acetylated at the 5- and 6-positions of 3-β-galactofuranose, as well as the 2-position of 6-β-galactofuranose. However, serotype 42 has only O-acetylation at 3-β-galactofuranose, an observation consistent with its loss of WciG functionality, which is associated with O-acetylation at the 2-position and subsequent reaction with typing antiserum 35a. These findings provide a comprehensive view of the genetic, biochemical structural, and serological bases of serotypes 35C and 42.
Streptococcus pneumoniae, capsular polysaccharide, serotyping, O-acetyltransferase, biochemical structure, genetic basis, serological profile
NCBI PubMed ID: 28659323Publication DOI: 10.1128/JCM.00822-17Journal NLM ID: 7505564Publisher: American Society for Microbiology
Correspondence: Moon H. Nahm
; Jinghua Yang
Institutions: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland, USA, Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Methods: 13C NMR, 1H NMR, NMR-2D, DNA sequencing, DNA techniques, ELISA, biochemical methods, SEC, flow cytometric serotyping assays
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9. Compound ID: 14898
|
a-D-Glcp-(1-2)-+ a-D-Glcp-(1-2)-+ a-D-Glcp-(1-2)-+ a-D-Glcp-(1-2)-+
| | | |
{{{-a-L-Rhap-(1-3)-a-L-Rhap-(1-2)-a-L-Rhap-(1-3)-a-L-Rhap-(1-2)-}}}a-L-Rhap-(1-3)-a-L-Rhap-(1-2)-a-L-Rhap-(1-3)-a-L-Rhap-(1--P--6)--{{{-Man-ol-(4--P--6)--}}}/n=2-5/-Man-ol-(4-P |
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Structure type: oligomer
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705,IEDB_133754,IEDB_136105,IEDB_142488,IEDB_143254,IEDB_144998,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 5832
Pyclik M, Srutkova D, Schwarzer M, Gorska S "Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - their chemical structure and biological attributes" -
International Journal of Biological Macromolecules 147 (2020) 333-349
A variety of health benefits has been documented to be associated with the consumption of probiotic bacteria, namely bifidobacteria and lactobacilli. Thanks to the scientific advances in recent years we are beginning to understand the molecular mechanisms by which bacteria in general and probiotic bacteria in particular act as host physiology and immune system modulators. More recently, the focus has shifted from live bacteria towards bacteria-derived defined molecules, so called postbiotics. These molecules may represent safer alternative compared to the live bacteria while retaining the desired effects on the host. The excellent source of effector macromolecules is the bacterial envelope. It contains compounds that are pivotal in the adhesion phenomenon, provide direct bacteria-to-host signaling capacity and the associated physiological impact and immunomodulatory properties of bacteria. Here we comprehensively review the structure and biological role of Bifidobacterium surface and cell wall molecules: exopolysaccharides, cell wall polysaccharides, lipoteichoic acids, polar lipids, peptidoglycans and proteins. We discuss their involvement in direct signaling to the host cells and their described immunomodulatory effects.
exopolysaccharide, Bacterial antigens, Bifidobacterium, peptidoglycan, lipoteichoic acid, probiotics
NCBI PubMed ID: 31899242Publication DOI: 10.1016/j.ijbiomac.2019.12.227Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: schwarzer@biomed.cas.cz; sabina.gorska@hirszfeld.pl
Institutions: Laboratory of Microbiome Immunobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic
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10. Compound ID: 14899
|
a-D-Glcp-(1-3)-+ a-D-Glcp-(1-3)-+
| |
{{{-a-L-Rhap-(1-2)-a-L-Rhap-(1-2)-}}}a-L-Rhap-(1-2)-a-L-Rhap-(1--P--6)--{{{-Man-ol-(4--P--6)--}}}/n=2-5/-Man-ol-(4-P |
Show graphically |
Structure type: oligomer
Compound class: teichoic acid
Contained glycoepitopes: IEDB_114705,IEDB_133754,IEDB_136105,IEDB_142488,IEDB_144825,IEDB_144998,IEDB_146664,IEDB_158539,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 5832
Pyclik M, Srutkova D, Schwarzer M, Gorska S "Bifidobacteria cell wall-derived exo-polysaccharides, lipoteichoic acids, peptidoglycans, polar lipids and proteins - their chemical structure and biological attributes" -
International Journal of Biological Macromolecules 147 (2020) 333-349
A variety of health benefits has been documented to be associated with the consumption of probiotic bacteria, namely bifidobacteria and lactobacilli. Thanks to the scientific advances in recent years we are beginning to understand the molecular mechanisms by which bacteria in general and probiotic bacteria in particular act as host physiology and immune system modulators. More recently, the focus has shifted from live bacteria towards bacteria-derived defined molecules, so called postbiotics. These molecules may represent safer alternative compared to the live bacteria while retaining the desired effects on the host. The excellent source of effector macromolecules is the bacterial envelope. It contains compounds that are pivotal in the adhesion phenomenon, provide direct bacteria-to-host signaling capacity and the associated physiological impact and immunomodulatory properties of bacteria. Here we comprehensively review the structure and biological role of Bifidobacterium surface and cell wall molecules: exopolysaccharides, cell wall polysaccharides, lipoteichoic acids, polar lipids, peptidoglycans and proteins. We discuss their involvement in direct signaling to the host cells and their described immunomodulatory effects.
exopolysaccharide, Bacterial antigens, Bifidobacterium, peptidoglycan, lipoteichoic acid, probiotics
NCBI PubMed ID: 31899242Publication DOI: 10.1016/j.ijbiomac.2019.12.227Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: schwarzer@biomed.cas.cz; sabina.gorska@hirszfeld.pl
Institutions: Laboratory of Microbiome Immunobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic
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11. Compound ID: 16320
|
-6)-a-D-ManpNAc3Ac-(1-4)-b-D-Galp-(1-3)-b-D-FucpNAc4N-(1-3)-Man-ol-(1-P- |
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Structure type: polymer chemical repeating unit
Compound class: O-antigen
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_137472,IEDB_141794,IEDB_142345,IEDB_149549,IEDB_149550,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 6329
Vinogradov E, St Michael F, Cairns C, Cox AD "The structure of the LPS O-chain from five Fusobacterium nucleatum strains CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, containing alditol and phosphate in the main chain and development of mouse monoclonal antibodies specific to the O-antigens" -
Carbohydrate Research 521 (2022) 108648
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and stillbirths. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report four new structures of the lipopolysaccharide O-chain (OPS) from five strains of F. nucleatum CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, isolated from cancerous tissues. Three of the four structures have a common sequence of hexose-diaminofucose-hexitol-phosphate in the main chain.
Lipopolysaccharide, NMR, structure, O-antigen, Fusobacterium nucleatum
NCBI PubMed ID: 36030633Publication DOI: 10.1016/j.carres.2022.108648Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: E. Vinogradov
Institutions: Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada, Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, Canada
Methods: 13C NMR, 1H NMR, NMR-2D, GC-MS, sugar analysis, ELISA, 31P NMR, ESI-MS, acid hydrolysis, de-O-acetylation, GPC, HF treatment, SEC, immunization, hybridoma selection
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12. Compound ID: 16321
Structure type: oligomer
; 734.5 [M+H]+
Compound class: O-antigen
Contained glycoepitopes: IEDB_114705,IEDB_136044,IEDB_137472,IEDB_141794,IEDB_142345,IEDB_149549,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 6329
Vinogradov E, St Michael F, Cairns C, Cox AD "The structure of the LPS O-chain from five Fusobacterium nucleatum strains CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, containing alditol and phosphate in the main chain and development of mouse monoclonal antibodies specific to the O-antigens" -
Carbohydrate Research 521 (2022) 108648
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and stillbirths. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report four new structures of the lipopolysaccharide O-chain (OPS) from five strains of F. nucleatum CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, isolated from cancerous tissues. Three of the four structures have a common sequence of hexose-diaminofucose-hexitol-phosphate in the main chain.
Lipopolysaccharide, NMR, structure, O-antigen, Fusobacterium nucleatum
NCBI PubMed ID: 36030633Publication DOI: 10.1016/j.carres.2022.108648Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: E. Vinogradov
Institutions: Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada, Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, Canada
Methods: 13C NMR, 1H NMR, NMR-2D, GC-MS, sugar analysis, ELISA, 31P NMR, ESI-MS, acid hydrolysis, de-O-acetylation, GPC, HF treatment, SEC, immunization, hybridoma selection
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13. Compound ID: 17216
Structure type: oligomer
Contained glycoepitopes: IEDB_114705,IEDB_130701,IEDB_144983,IEDB_152206,IEDB_983930,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6734
Iwahara S, Suemori N, Ramli N, Takegawa K "Isolation and identification of novel acidic oligosaccharides derived from glycoproteins of Fusarium sp M7-1" -
Bioscience, Biotechnology, and Biochemistry 59 (1995) 1082-1085
Journal NLM ID: 9205717Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
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14. Compound ID: 17217
Structure type: oligomer
Contained glycoepitopes: IEDB_114705,IEDB_130701,IEDB_136104,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6734
Iwahara S, Suemori N, Ramli N, Takegawa K "Isolation and identification of novel acidic oligosaccharides derived from glycoproteins of Fusarium sp M7-1" -
Bioscience, Biotechnology, and Biochemistry 59 (1995) 1082-1085
Journal NLM ID: 9205717Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
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15. Compound ID: 17218
Structure type: oligomer
Contained glycoepitopes: IEDB_114705,IEDB_130701,IEDB_136104,IEDB_136105,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_225177,IEDB_885823,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 6734
Iwahara S, Suemori N, Ramli N, Takegawa K "Isolation and identification of novel acidic oligosaccharides derived from glycoproteins of Fusarium sp M7-1" -
Bioscience, Biotechnology, and Biochemistry 59 (1995) 1082-1085
Journal NLM ID: 9205717Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Next 15 structure(s)
Total list of structure IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (permanent record IDs):
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