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Structure type: oligomer ; 786.2887
C₄₃H₄₆O₁₄
Trivial name: moromycin A
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47251 (all data & tools)

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Structure type: oligomer ; 562.1844
C₃₁H₃₀O₁₀
Trivial name: moromycin B
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47252 (all data & tools)

Show legend Show as text

Structure type: oligomer
C₄₃H₄₈O₁₆
Trivial name: saquayamycin B
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47253 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: fridamycin D
Compound class: glycoside

• Article ID: 5542
  Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J "Moromycins A and B: Isolation and structure elucidation of C-glycosylangucycline type antibiotics from Streptomyces sp.KY002" - Journal of Natural Products 71(9) (2008) 1569-1573
  

  Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

  Streptomyces, glycosides, antibiotics, moromycins, saquayamycin B, fridamycin D

  NCBI PubMed ID: 18666798
  Publication DOI: 10.1021/np800281f
  Journal NLM ID: 7906882
  Publisher: American Society of Pharmacognosy
  Correspondence: jrohr2@email.uky.edu
  Institutions: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
  Methods: 13C NMR, 1H NMR, NMR-2D, IR, FAB-MS, DNA techniques, ESI-MS, HPLC, UV, extraction, optical rotation measurement, CI-MS, cell growth, HPLC-MS, cytotoxicity assay, antitumor activity assay, evaporation, centrifugation
  
   
  
  Streptomyces sp. KY002
  CSDB ID 47254 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: fridamycin D
Compound class: glycoside

• Article ID: 5595
  Maskey RP, Helmke E, Laatsch H "Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate" - The Journal of Antibiotics 56(11) (2003) 942-949
  

  In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was determined by comparison of the NMR data with those of fridamycin D (2b) and by detailed interpretation of mass, 1D and 2D NMR spectra

  Streptomyces, Marine bacteria, antibiotics, himalomycins

  NCBI PubMed ID: 14763560
  Publication DOI: 10.7164/antibiotics.56.942
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: hlaatsc@gwdg.de
  Institutions: Department of Organic Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegner-Institute for Polar and Marine Research, Bremerhaven, Germany
  Methods: 13C NMR, 1H NMR, IR, HPLC, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, antibacterial assay, APT
  
   
  
  Streptomyces sp. B6921
  CSDB ID 47711 (all data & tools)

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Structure type: oligomer
Trivial name: hymalomycin A
Compound class: glycoside

• Article ID: 5595
  Maskey RP, Helmke E, Laatsch H "Himalomycin A and B: isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate" - The Journal of Antibiotics 56(11) (2003) 942-949
  

  In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was determined by comparison of the NMR data with those of fridamycin D (2b) and by detailed interpretation of mass, 1D and 2D NMR spectra

  Streptomyces, Marine bacteria, antibiotics, himalomycins

  NCBI PubMed ID: 14763560
  Publication DOI: 10.7164/antibiotics.56.942
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: hlaatsc@gwdg.de
  Institutions: Department of Organic Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegner-Institute for Polar and Marine Research, Bremerhaven, Germany
  Methods: 13C NMR, 1H NMR, IR, HPLC, UV, extraction, optical rotation measurement, CC, cell growth, HR-ESI-MS, antibacterial assay, APT
  
   
  
  Streptomyces sp. B6921
  CSDB ID 47712 (all data & tools)