Show legend Show as text

Structure type: oligomer
Trivial name: trioxacarcin A
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47373 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: trioxacarcin B
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47374 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: trioxacarcin C
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47375 (all data & tools)

Show legend Show as text

Structure type: oligomer ; 833.2988 [M-H]-
C₄₀H₅₀O₁₉
Trivial name: trioxacarcin D
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47376 (all data & tools)

Show legend Show as text

Structure type: oligomer ; 911 [M-H]-, 935 [M+Na]+
C₄₂H₅₈O₂₂
Trivial name: trioxacarcin F
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47377 (all data & tools)

Show legend Show as text

Structure type: oligomer
Trivial name: gutingimycin
Compound class: glycoside

• Article ID: 5574
  Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H "Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry" - The Journal of Antibiotics 57(12) (2004) 771-779
  

  The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A to approximately C (2a to approximately 2c) and additionally three new derivatives designated as trioxacarcins D to approximately F (2d to approximately 2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The structures of the new antibiotics were derived from mass, 1D and 2D NMR spectra and confirmed by comparison of the NMR data with those of known derivatives. The absolute configuration of the trioxacarcins is deduced from the X-ray analysis of gutingimycin (2g) and from the known stereochemistry of the L-trioxacarcinoses A and B

  Streptomyces, antibacterial, trioxacarcins

  NCBI PubMed ID: 15745111
  Publication DOI: 10.7164/antibiotics.57.771
  Journal NLM ID: 0151115
  Publisher: London: Nature Publishing Group
  Correspondence: HLAATSC@gwdg.de
  Institutions: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen, Germany, Alfred-Wegener-Institute for Polar and Marine Research, Bremerhaven, Germany, Rijksuniversiteit Groningen, Farmaceutische Biologie, Groningen, The Netherlands, Oncotest GmbH, Freiburg, Germany, Department of Genetechnology, Fraunhofer Institut IGB, Hannover, Germany
  Methods: 13C NMR, 1H NMR, NMR-2D, X-ray, fluorescence spectroscopy, CC, cell growth, HR-ESI-MS, antitumor activity assay, antimicrobial assay
  
   
  
  Streptomyces sp. B8652
  CSDB ID 47378 (all data & tools)