Found 56 structures.
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1. Compound ID: 167
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3HOMyr-(1-3)-+ 3HOPam-(1-2)-+
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Myr-(1-3)-3HOPam-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1---P---P---1)-L-Arap4N
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P-4)-+ 3HOMyr-(1-3)-+ |
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Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_135394,IEDB_135515,IEDB_141807,IEDB_151531,IEDB_176772
The structure is contained in the following publication(s):
- Article ID: 37
Caroff M, Karibian D "Structure of bacterial lipopolysaccharides" -
Carbohydrate Research 338(23) (2003) 2431-2447
Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria They are often of interest in medicine for their immunomodulatory properties. In small amounts they can be beneficial, but in larger amounts they may cause endotoxic shock. Although they share a common architecture, their structural details exert a strong influence on their activity. These molecules comprise: a lipid moiety, called lipid A, which is considered to be the endotoxic component, a glycosidic part consisting of a core of approximately 10 monosaccharides and, in 'smooth-type' lipopolysaccharides, a third region, named O-chain, consisting of repetitive subunits of one to eight monosaccharides responsible for much of the immunospecificity of the bacterial cell.
Lipopolysaccharide, structure, core, lipid A, endotoxin, O-chains
NCBI PubMed ID: 14670707Publication DOI: 10.1016/j.carres.2003.07.010Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: martine.carloff@bbmpc.u-psud.fr
Institutions: Equipe Endotoxines, UMR 8619 du Centre National de la Recherche Scientifique, IBBMC, Université de Paris-Sud, F-Orsay, France
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2. Compound ID: 169
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Pam-(1-3)-3HOMyr-(1-3)-+
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L-Arap4N-(1--P--4)--+ |
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Pam-(1-3)-3HOMyr-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1--P--1)--D-Araf
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3HOMyr-(1-3)-+ 3HOMyr-(1-2)-+ |
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Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_135394,IEDB_135515,IEDB_141181,IEDB_141807,IEDB_151531
The structure is contained in the following publication(s):
- Article ID: 37
Caroff M, Karibian D "Structure of bacterial lipopolysaccharides" -
Carbohydrate Research 338(23) (2003) 2431-2447
Bacterial lipopolysaccharides are the major components of the outer surface of Gram-negative bacteria They are often of interest in medicine for their immunomodulatory properties. In small amounts they can be beneficial, but in larger amounts they may cause endotoxic shock. Although they share a common architecture, their structural details exert a strong influence on their activity. These molecules comprise: a lipid moiety, called lipid A, which is considered to be the endotoxic component, a glycosidic part consisting of a core of approximately 10 monosaccharides and, in 'smooth-type' lipopolysaccharides, a third region, named O-chain, consisting of repetitive subunits of one to eight monosaccharides responsible for much of the immunospecificity of the bacterial cell.
Lipopolysaccharide, structure, core, lipid A, endotoxin, O-chains
NCBI PubMed ID: 14670707Publication DOI: 10.1016/j.carres.2003.07.010Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: martine.carloff@bbmpc.u-psud.fr
Institutions: Equipe Endotoxines, UMR 8619 du Centre National de la Recherche Scientifique, IBBMC, Université de Paris-Sud, F-Orsay, France
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3. Compound ID: 348
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3HOMyr-(1-2)-+
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Pam-(1-3)-3HOMyr-(1-3)-+ |
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?%Arap4N-(1--P--4)--+ | |
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Pam-(1-3)-3HOMyr-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN
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3HOMyr-(1-3)-+ |
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?%Araf-(1--P--1)--+ |
Show graphically |
Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_136907,IEDB_141181,IEDB_141807,IEDB_151531
The structure is contained in the following publication(s):
- Article ID: 99
Therisod H, Karibian D, Perry MB, Caroff M "Structural analysis of Yersinia pseudotuberculosis ATCC 29833 lipid A" -
International Journal of Mass Spectrometry 219(3) (2002) 549-557
The Yersinia genus includes human and animal pathogens (plague, enterocolitis) as well as non-pathogens. The lipopolysaccharide of the facultative pathogen Yersinia pseudotuberculosis has been implicated in the invasiveness of these bacteria. In this work, we have investigated the fine structure of the lipid A isolated from Y. pseudotuberculosis lipopolysaccharide using chemical analyses, gas chromatography/mass spectrometry, plasma desorption mass spectrometry, and matrix-assisted laser desorption mass spectrometry. Arabinose (Ara) and aminoarabinose (Ara-4N) esterified the phosphates as in Yersinia pestis lipid A. The acylation of Y. pseudotuberculosis lipid A differed from those found in Yersinia enterocolitica, Yersinia ruckeri, and Y. pestis lipopolysaccharides (LPSs): in the distribution of fatty acids between the two glucosamines in the fully acylated hexaacyl molecular species and by the acyloxyacyl substitution at position C-2′, where the Y. pseudotuberculosis lipid A has a C14OC16 making it closest to that of Y. pestis.
lipid A, endotoxin, Yersinia pseudotuberculosis, Y. pseudotuberculosis, PDMS, MALDI
Publication DOI: 10.1016/S1387-3806(02)00706-6Journal NLM ID: 101137096Publisher: Elsevier
Correspondence: martine.caroff@bbmpc.u-psud.fr
Institutions: Equipe “Endotoxines”, UMR 8619 du CNRS, I.B.B.M.C., Université de Paris-Sud, F-Orsay, France, Institute for Biological Sciences, NRC, Ottawa, Ont., Canada
Methods: GC-MS, SDS-PAGE, TLC, ESI-MS, GC, MALDI-TOF MS, composition analysis, mild alkaline degradation, PD-MS
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4. Compound ID: 349
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3HOMyr-(1-3)-+
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?%Ara-(1--P--1)--+ |
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Lau-(1-3)-3HOMyr-(1-3)-+ | |
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C16={11}-(1-3)-3HOMyr-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN
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?%Arap4N-(1--P--4)--+ 3HOMyr-(1-2)-+ |
Show graphically |
Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_136907,IEDB_141807,IEDB_151531,IEDB_534864,IEDB_581506
The structure is contained in the following publication(s):
- Article ID: 99
Therisod H, Karibian D, Perry MB, Caroff M "Structural analysis of Yersinia pseudotuberculosis ATCC 29833 lipid A" -
International Journal of Mass Spectrometry 219(3) (2002) 549-557
The Yersinia genus includes human and animal pathogens (plague, enterocolitis) as well as non-pathogens. The lipopolysaccharide of the facultative pathogen Yersinia pseudotuberculosis has been implicated in the invasiveness of these bacteria. In this work, we have investigated the fine structure of the lipid A isolated from Y. pseudotuberculosis lipopolysaccharide using chemical analyses, gas chromatography/mass spectrometry, plasma desorption mass spectrometry, and matrix-assisted laser desorption mass spectrometry. Arabinose (Ara) and aminoarabinose (Ara-4N) esterified the phosphates as in Yersinia pestis lipid A. The acylation of Y. pseudotuberculosis lipid A differed from those found in Yersinia enterocolitica, Yersinia ruckeri, and Y. pestis lipopolysaccharides (LPSs): in the distribution of fatty acids between the two glucosamines in the fully acylated hexaacyl molecular species and by the acyloxyacyl substitution at position C-2′, where the Y. pseudotuberculosis lipid A has a C14OC16 making it closest to that of Y. pestis.
lipid A, endotoxin, Yersinia pseudotuberculosis, Y. pseudotuberculosis, PDMS, MALDI
Publication DOI: 10.1016/S1387-3806(02)00706-6Journal NLM ID: 101137096Publisher: Elsevier
Correspondence: martine.caroff@bbmpc.u-psud.fr
Institutions: Equipe “Endotoxines”, UMR 8619 du CNRS, I.B.B.M.C., Université de Paris-Sud, F-Orsay, France, Institute for Biological Sciences, NRC, Ottawa, Ont., Canada
Methods: GC-MS, SDS-PAGE, TLC, ESI-MS, GC, MALDI-TOF MS, composition analysis, mild alkaline degradation, PD-MS
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5. Compound ID: 350
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Lau-(1-3)-3HOMyr-(1-3)-+ 3HOMyr-(1-2)-+
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Lau-(1-3)-3HOMyr-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P
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?%Arap4N-(1--P--4)--+ 3HOMyr-(1-3)-+ |
Show graphically |
Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_135394,IEDB_135515,IEDB_141807,IEDB_151531,IEDB_534864
The structure is contained in the following publication(s):
- Article ID: 99
Therisod H, Karibian D, Perry MB, Caroff M "Structural analysis of Yersinia pseudotuberculosis ATCC 29833 lipid A" -
International Journal of Mass Spectrometry 219(3) (2002) 549-557
The Yersinia genus includes human and animal pathogens (plague, enterocolitis) as well as non-pathogens. The lipopolysaccharide of the facultative pathogen Yersinia pseudotuberculosis has been implicated in the invasiveness of these bacteria. In this work, we have investigated the fine structure of the lipid A isolated from Y. pseudotuberculosis lipopolysaccharide using chemical analyses, gas chromatography/mass spectrometry, plasma desorption mass spectrometry, and matrix-assisted laser desorption mass spectrometry. Arabinose (Ara) and aminoarabinose (Ara-4N) esterified the phosphates as in Yersinia pestis lipid A. The acylation of Y. pseudotuberculosis lipid A differed from those found in Yersinia enterocolitica, Yersinia ruckeri, and Y. pestis lipopolysaccharides (LPSs): in the distribution of fatty acids between the two glucosamines in the fully acylated hexaacyl molecular species and by the acyloxyacyl substitution at position C-2′, where the Y. pseudotuberculosis lipid A has a C14OC16 making it closest to that of Y. pestis.
lipid A, endotoxin, Yersinia pseudotuberculosis, Y. pseudotuberculosis, PDMS, MALDI
Publication DOI: 10.1016/S1387-3806(02)00706-6Journal NLM ID: 101137096Publisher: Elsevier
Correspondence: martine.caroff@bbmpc.u-psud.fr
Institutions: Equipe “Endotoxines”, UMR 8619 du CNRS, I.B.B.M.C., Université de Paris-Sud, F-Orsay, France, Institute for Biological Sciences, NRC, Ottawa, Ont., Canada
Methods: GC-MS, SDS-PAGE, TLC, ESI-MS, GC, MALDI-TOF MS, composition analysis, mild alkaline degradation, PD-MS
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6. Compound ID: 351
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Lau-(1-3)-3HOMyr-(1-3)-+ 3HOMyr-(1-2)-+
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Myr-(1-3)-3HOMyr-(1-2)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P
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?%Arap4N-(1--P--4)--+ 3HOMyr-(1-3)-+ |
Show graphically |
Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_135394,IEDB_135515,IEDB_141807,IEDB_151531,IEDB_176772,IEDB_534864
The structure is contained in the following publication(s):
- Article ID: 99
Therisod H, Karibian D, Perry MB, Caroff M "Structural analysis of Yersinia pseudotuberculosis ATCC 29833 lipid A" -
International Journal of Mass Spectrometry 219(3) (2002) 549-557
The Yersinia genus includes human and animal pathogens (plague, enterocolitis) as well as non-pathogens. The lipopolysaccharide of the facultative pathogen Yersinia pseudotuberculosis has been implicated in the invasiveness of these bacteria. In this work, we have investigated the fine structure of the lipid A isolated from Y. pseudotuberculosis lipopolysaccharide using chemical analyses, gas chromatography/mass spectrometry, plasma desorption mass spectrometry, and matrix-assisted laser desorption mass spectrometry. Arabinose (Ara) and aminoarabinose (Ara-4N) esterified the phosphates as in Yersinia pestis lipid A. The acylation of Y. pseudotuberculosis lipid A differed from those found in Yersinia enterocolitica, Yersinia ruckeri, and Y. pestis lipopolysaccharides (LPSs): in the distribution of fatty acids between the two glucosamines in the fully acylated hexaacyl molecular species and by the acyloxyacyl substitution at position C-2′, where the Y. pseudotuberculosis lipid A has a C14OC16 making it closest to that of Y. pestis.
lipid A, endotoxin, Yersinia pseudotuberculosis, Y. pseudotuberculosis, PDMS, MALDI
Publication DOI: 10.1016/S1387-3806(02)00706-6Journal NLM ID: 101137096Publisher: Elsevier
Correspondence: martine.caroff@bbmpc.u-psud.fr
Institutions: Equipe “Endotoxines”, UMR 8619 du CNRS, I.B.B.M.C., Université de Paris-Sud, F-Orsay, France, Institute for Biological Sciences, NRC, Ottawa, Ont., Canada
Methods: GC-MS, SDS-PAGE, TLC, ESI-MS, GC, MALDI-TOF MS, composition analysis, mild alkaline degradation, PD-MS
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7. Compound ID: 375
Structure type: oligomer
Compound class: lipid A
The structure is contained in the following publication(s):
- Article ID: 119
Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CRH "Accumulation of a polyisoprene-linked amino sugar in polymyxin resistant Salmonella typhimurium and Escherichia coli. Structural characterization and transfer to lipid A in the periplasm" -
Journal of Biological Chemistry 276(46) (2001) 43132-43144
Polymyxin-resistant mutants of Escherichia coli and Salmonella typhimurium accumulate a novel minor lipid that can donate 4-amino-4-deoxy-l-arabinose units (l-Ara4N) to lipid A. We now report the purification of this lipid from a pss(-) pmrA(C) mutant of E. coli and assign its structure as undecaprenyl phosphate-α-L-Ara4N. Approximately 0.2 mg of homogeneous material was isolated from an 8-liter culture by solvent extraction, followed by chromatography on DEAE-cellulose, C18 reverse phase resin, and silicic acid. Matrix-assisted laser desorption ionization/time of flight mass spectrometry in the negative mode yielded a single species [M - H](-) at m/z 977.5, consistent with undecaprenyl phosphate-α-L-Ara4N (M(r) = 978.41). (31)P NMR spectroscopy showed a single phosphorus atom at -0.44 ppm characteristic of a phosphodiester linkage. Selective inverse decoupling difference spectroscopy demonstrated that the undecaprenyl phosphate group is attached to the anomeric carbon of the l-Ara4N unit. One- and two-dimensional (1)H NMR studies confirmed the presence of a polyisoprene chain and a sugar moiety with chemical shifts and coupling constants expected for an equatorially substituted arabinopyranoside. Heteronuclear multiple-quantum coherence spectroscopy analysis demonstrated that a nitrogen atom is attached to C-4 of the sugar residue. The purified donor supports in vitro conversion of lipid IV(A) to lipid II(A), which is substituted with a single l-Ara4N moiety. The identification of undecaprenyl phosphate-α-L-Ara4N implies that l-Ara4N transfer to lipid A occurs in the periplasm of polymyxin-resistant strains, and establishes a new enzymatic pathway by which Gram-negative bacteria acquire antibiotic resistance.
Escherichia coli, lipid A, polymyxin-resistant mutants, Salmonella typhimurium
NCBI PubMed ID: 11535605Publication DOI: 10.1074/jbc.M106962200Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Correspondence: raetz@biochem.duke.edu
Institutions: Department of Biochemistry and the Duke NMR Spectroscopy Center and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, Middle Atlantic Mass Spectrometry Laboratory, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA
Methods: 13C NMR, 1H NMR, NMR-2D, DNA techniques, TLC, 31P NMR, MALDI-TOF MS, radiolabeling, NMR-1D, genetic methods, biochemical methods, radioactivity measurement
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8. Compound ID: 691
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ b-D-Glcp-(1-4)-+ a-Kdop-(2-4)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN |
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Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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9. Compound ID: 692
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ b-D-Glcp-(1-4)-+ a-Kop-(2-4)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN |
Show graphically |
Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130670,IEDB_135607,IEDB_135609,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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10. Compound ID: 693
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-+ | b-D-Glcp-(1-4)-+ L-Arap4N-(1-8)-+ | |
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b-D-Glcp-(1-6)-a-D-Glcp-(1-4)-a-D-GlcpN-(1-4)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN
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a-Kdop-(2-4)-+ |
Show graphically |
Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141806,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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11. Compound ID: 694
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-+ | b-D-Glcp-(1-4)-+ L-Arap4N-(1-8)-+ | |
| | | | | |
b-D-Glcp-(1-6)-a-D-Glcp-(1-4)-a-D-GlcpN-(1-4)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN
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a-Kop-(2-4)-+ |
Show graphically |
Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130670,IEDB_135607,IEDB_135609,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141806,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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12. Compound ID: 695
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ b-D-Glcp-(1-4)-+ L-Arap4N-(1-8)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN
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a-Kop-(2-4)-+ |
Show graphically |
Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130670,IEDB_135607,IEDB_135609,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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13. Compound ID: 696
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?%L-Arap4N-(1--P--1)--+
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?%L-Arap4N-(1--P--4)--+ |
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L-gro-a-D-manHepp-(1-7)-+ b-D-Glcp-(1-4)-+ L-Arap4N-(1-8)-+ | |
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L-gro-a-D-manHepp-(1-2)-D-gro-a-D-manHepp-(1-2)-a-D-GalpA-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN
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a-Kdop-(2-4)-+ |
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Structure type: oligomer
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189046,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 186
Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O "The structures of the core-lipid A regions of lipopolysaccharides from Serratia marcescens" -
Proceedings of International Carbohydrate Symposium (21st : 2002 : Cairns, Queensland) (2002) 279
Lipopolysaccharide, lipopolysaccharides, structure, core, carbohydrate, Serratia marcescens, region, core-lipid A region, Serratia, structue
Institutions: Institute for Biological Sciences, NRCC, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada, Division of Biophysics, Research Center Borstel, Parkallee 10, D-23845 Borstel, Germany, Robert-Koch-Institute, Burgstr. 37, D-38855 Wernigerode, Germany, Institute of Microbiology, Silesian University, Jagiellonska 28, PL-40-032 Katowice, Poland, Division of Structural Biochemistry, Research Center Borstel, Borstel, Germany
Methods: NMR, chemical analysis, mild acid hydrolysis, deamination, de-O-acylation with hydrazine, alkaline deacylation
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14. Compound ID: 1242
Structure type: monomer
The structure is contained in the following publication(s):
- Article ID: 383
Soininen A, Pursiainen H, Kilpi T, Käyhty H "Natural development of antibodies to pneumococcal capsular polysaccharides depends on the serotype: Association with pneumococcal carriage and acute otitis media in young children" -
Journal of Infectious Diseases 184(5) (2001) 569-576
To study the natural development of antibodies to pneumococcal capsular polysaccharides of types 1, 6B, 11A, 14, 19F, and 23F and its association with pneumococcal carriage and acute otitis media (AOM), 329 children were followed-up prospectively during their first 2 years of life. Nasopharyngeal carriage was determined by cultures of nasopharyngeal swab samples, and etiology of AOM was determined by cultures of middle ear fluid. Antibodies were measured in serum samples collected at 6, 12, 18, and 24 months by EIA. Antibodies increased modestly but significantly with age. Contact with serotypes 11A and 14 was associated with increased antibody concentration as early as age 6 months. Children with contact with serotypes 6B, 19F, and 23F had antibody levels similar to those in children without contact. Antibodies increased modestly, even in children without known contact with Streptococcus pneumoniae and in children with contact with heterologous serotypes. Antibody concentrations were equal after carriage or AOM.
serotype, antibodies, polysaccharides, otitis media, acute, child, disease transmission, serum specimen
NCBI PubMed ID: 11494163Journal NLM ID: 0413675Publisher: Oxford: Oxford University Press
Correspondence: raetz@biochem.duke.edu
Institutions: Department of Biochemistry, Duke University Medical Center, Department of Radiology and the Duke NMR Spectroscopy Center, Duke University Medical Center, Durham, North Carolina 27710
Methods: NMR, genetic methods
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15. Compound ID: 1296
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Arap4N-(1--P--?)--+ LIP-(?-?)-+
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b-L-Arap4N-(1-8)-a-Kop-(2-4)-Kdop-(2-?)-D-GlcpN-(1-?)-D-GlcpN-(1--P--1)--Arap4N
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LIP-(?-?)-+ |
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Structure type: oligomer
Compound class: lipid A
Contained glycoepitopes: IEDB_130650,IEDB_135394,IEDB_135607,IEDB_135609,IEDB_141807,IEDB_151531
The structure is contained in the following publication(s):
- Article ID: 405
Vinion-Dubiel AD, Goldberg JB "Lipopolysaccharide of Burkholderia cepacia complex" -
Journal of Endotoxin Research 9(4) (2003) 201-213
Burkholderia cepacia complex (Bcc) is a group of phenotypically similar, genetically distinct bacteria that are beneficial to the environment but can also cause severe human infections. Bcc are being exploited for use as bioremediation agents and as a way to combat agricultural plant diseases. However, Bcc can cause lung infections in patients with chronic granulomatous disease or cystic fibrosis often resulting in mortality of these patients. Since it is unclear what bacterial components are necessary for causing human infections, studies of Bcc have focused on identifying putative virulence factors. As in other Gram-negative bacteria, the lipopolysaccharide (LPS) of Bcc induces a strong immune response that can contribute to host cell damage. The unusual structure of Bcc LPS lowers the anionic charge of the Bcc cell surface, which inhibits the binding and subsequent effects of cationic antibiotics. These distinguishing features include the substitution of a Ko for a Kdo residue in the inner core oligosaccharide and Ara4N residues bound to phosphates of the lipid A backbone. The structures of O antigen subunits and the consequent serotypes will also be discussed, with particular reference to the O antigen biosynthetic loci of two Bcc strains.
Lipopolysaccharide, structure, Burkholderia, Burkholderia cepacia, O-antigen, complex, endotoxin, Re
NCBI PubMed ID: 12935351Publication DOI: 10.1177/09680519030090040101Journal NLM ID: 9433350Publisher: Maney Publishing
Institutions: Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908-0734, USA
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