Found 7 structures.
Displayed structures from 1 to 7
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1. Compound ID: 2959
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a-D-GlcN-(1-7)-+ b-D-Sedf-(2-6)-b-D-Glc-(1-4)-+ P-4)-+
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b-D-Sedf-(2-3)-b-D-Gal-(1-3)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2--/lipid A/
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a-D-Glc-(1-6)-+ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 1048
Nesper J, Kraiss A, Schild S, Blabeta J, Klose KE, Bockemuhl J, Reidl J "Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster" -
Infection and Immunity 70(5) (2002) 2419-2433
We identified five different putative wav gene cluster types, which are responsible for the synthesis of the core oligosaccharide (OS) region of Vibrio cholerae lipopolysaccharide. Preliminary evidence that the genes encoded by this cluster are involved in core OS biosynthesis came from analysis of the recently released O1 El Tor V. cholerae genome sequence and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of O1 El Tor mutant strains defective in three genes (waaF, waaL, and wavB). Investigations of 38 different V. cholerae strains by Southern blotting, PCR, and sequencing analyses showed that the O1 El Tor wav gene cluster type is prevalent among clinical isolates of different serogroups associated with cholera and environmental O1 strains. In contrast, we found differences in the wav gene contents of 19 unrelated non-O1, non-O139 environmental and human isolates not associated with cholera. These strains contained four new wav gene cluster types that differ from each other in distinct gene loci, providing evidence for horizontal transfer of wav genes and for limited structural diversity of the core OS among V. cholerae isolates. Our results show genetic diversity in the core OS biosynthesis gene cluster and predominance of the type 1 wav gene locus in strains associated with clinical cholera, suggesting that a specific core OS structure could contribute to V. cholerae virulence
Lipopolysaccharide, biosynthesis, genetic, synthesis, transfer, LPS, oligosaccharide, structure, core, blotting, clinical, gene, human, isolate, PCR, strain, structural, virulence, analysis, locus, type, core oligosaccharide, lipopolysaccharide core, lipopolysaccharide core oligosaccharide, cluster, gene cluster, specific, mutant, serogroup, putative, region, sequencing, sequence, difference, Vibrio, content, Vibrio cholerae, genome, gel electrophoresis, cholera, genetic diversity, diversity, electrophoresis, gel, environmental
NCBI PubMed ID: 11953379Journal NLM ID: 0246127Publisher: American Society for Microbiology
Correspondence: oachim.reidl@mail.uni-wuerzburg.de
Institutions: Zentrum fur Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany, Hygiene Institut Hamburg, Hamburg, Germany. University of Texas Health Science Center, San Antonio, Texas 78284-7758
Methods: genetic methods
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2. Compound ID: 5624
Structure type: oligomer
Compound class: O-polysaccharide, O-antigen
The structure is contained in the following publication(s):
- Article ID: 2437
Vinogradov EV, Holst O, Thomas-Oates JE, Broady KW, Brade H "The structure of the O-antigenic polysaccharide from lipopolysaccharide of Vibrio cholerae strain H11 (non-O1)" -
European Journal of Biochemistry 210 (1992) 491-498
After acid degradation of the lipopolysaccharide (LPS) of Vibrio cholerae strain H11 (non-O1), a tetrasaccharide was obtained, the structure of which was determined by quantitative and methylation analyses, periodate oxidation, one- and two-dimensional NMR spectroscopy, and fast-atom-bombardment and four-sector tandem mass spectrometry as β-D-GalANGro-(1-3)-β-D-QuiNAc-(1-4)-α-D-GalANGr o-(1-4)-NeuAc, in which GalANGro is N-galacturonoyl-2-aminoglycerol and QuiN 2-amino-2,6-dideoxy-glucopyranose. In addition, the trisaccharide β-D-GalANGro-(1-3)-β-D-QuiNAc-(1-4)-D-altro-hept ulose and the disaccharide α-D-GalANGro-(1-4)-NeuAc were isolated from acid-degraded lipopolysaccharide; the occurrence of sedoheptulose in lipopolysaccharide has not been described before. Based on the result of methylation analysis showing that galacturonic acid was the terminal sugar of the polysaccharide chain, and on the assumption that the tri- and the disaccharide represented the reducing and the non-reducing ends of the polysaccharide, respectively, the chemical structure of the O-specific chain of V. cholerae H11 is proposed as α-D-GalANGro-(1-4)-α-NeuAc-(2-3)-β-D-GalANGro-(1- 3)-β-D-QuiNAc- (1-[4)-α-D-GalANGro-(1-4)-α-NeuAc-(2-3)-β-D-GalANGro -(1-3)-β-D-QuiNAc-(1-]n-(1-4)-D-altro-heptulose. However, other possible structures can not be ruled out since the tri- and the disaccharide could be localised at different positions.
NCBI PubMed ID: 1281098Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
Institutions: Division of Biochemical Microbiology, Institut für Experimentelle Biologie und Medizin, Federal Republic of Germany
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3. Compound ID: 5660
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a-D-GlcN-(1-7)-+ b-D-Sedf-(2-6)-b-D-Glcp-(1-4)-+ P-4)-+ P-4)-+
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b-D-Sedf-(2-3)-b-D-Galp-(1-3)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P
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a-D-Glcp-(1-6)-+ |
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Structure type: oligomer
Compound class: LPS
Contained glycoepitopes: IEDB_130650,IEDB_135394,IEDB_136044,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_140956,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2460
Bock K, Vinogradov EV, Holst O, Brade H "Isolation and structural analysis of oligosaccharide phosphates containing the complete carbohydrate chain of the lipopolysaccharide from Vibrio cholerae strain H11 (non-01)" -
European Journal of Biochemistry 225 (1994) 1029-1039
Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
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4. Compound ID: 5661
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a-D-GlcN-(1-7)-+ b-D-Sedf-(2-6)-b-D-Glcp-(1-4)-+ P-4)-+ P-4)-+
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b-D-Galp-(1-3)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P
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a-D-Glcp-(1-6)-+ |
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Structure type: oligomer
Compound class: LPS
Contained glycoepitopes: IEDB_130650,IEDB_135394,IEDB_136044,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_140956,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2460
Bock K, Vinogradov EV, Holst O, Brade H "Isolation and structural analysis of oligosaccharide phosphates containing the complete carbohydrate chain of the lipopolysaccharide from Vibrio cholerae strain H11 (non-01)" -
European Journal of Biochemistry 225 (1994) 1029-1039
Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
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5. Compound ID: 6621
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a-D-GlcN-(1-7)-+ b-D-Sedf-(2-6)-b-D-Glcp-(1-4)-+ P-4)-+ P-4)-+
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b-L-4dthrHexp4enA-(1-4)-a-Neup-(2-3)-b-D-GalpA-(1-3)-b-D-QuipN-(1-4)-b-D-Sedf-(2-3)-b-D-Galp-(1-3)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P
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a-D-Glcp-(1-6)-+ |
Show graphically |
Structure type: oligomer
Contained glycoepitopes: IEDB_130650,IEDB_135394,IEDB_136044,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_140956,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 2460
Bock K, Vinogradov EV, Holst O, Brade H "Isolation and structural analysis of oligosaccharide phosphates containing the complete carbohydrate chain of the lipopolysaccharide from Vibrio cholerae strain H11 (non-01)" -
European Journal of Biochemistry 225 (1994) 1029-1039
Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
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6. Compound ID: 18376
Structure type: monomer
Compound class: phosphoglycan
The structure is contained in the following publication(s):
- Article ID: 7191
Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA "Riboneogenesis in yeast" -
Cell 145(6) (2011) 969-980
Glucose is catabolized in yeast via two fundamental routes, glycolysis and the oxidative pentose phosphate pathway, which produces NADPH and the essential nucleotide component ribose-5-phosphate. Here, we describe riboneogenesis, a thermodynamically driven pathway that converts glycolytic intermediates into ribose-5-phosphate without production of NADPH. Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate. In the pathway's committed step, sedoheptulose bisphosphate is hydrolyzed to sedoheptulose-7-phosphate by the enzyme sedoheptulose-1,7-bisphosphatase (SHB17), whose activity we identified based on metabolomic analysis of the corresponding knockout strain. The crystal structure of Shb17 in complex with sedoheptulose-1,7-bisphosphate reveals that the substrate binds in the closed furan form in the active site. Sedoheptulose-7-phosphate is ultimately converted by known enzymes of the nonoxidative pentose phosphate pathway to ribose-5-phosphate. Flux through SHB17 increases when ribose demand is high relative to demand for NADPH, including during ribosome biogenesis in metabolically synchronized yeast cells.
riboneogenesis
NCBI PubMed ID: 21663798Publication DOI: 10.1016/j.cell.2011.05.022Journal NLM ID: 0413066Publisher: Cambridge, MA: Cell Press
Correspondence: Rabinowitz JD
; Caudy AA
Institutions: Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, USA, Department of Chemical Engineering and Applied Chemistry, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Department of Chemistry, University of Tennessee, Knoxville, USA, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
Methods: crystallography, extraction, cell growth, LC-MS/MS, HPLC-MS, enzymatic assay
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7. Compound ID: 18377
Structure type: monomer
Compound class: phosphoglycan
The structure is contained in the following publication(s):
- Article ID: 7191
Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA "Riboneogenesis in yeast" -
Cell 145(6) (2011) 969-980
Glucose is catabolized in yeast via two fundamental routes, glycolysis and the oxidative pentose phosphate pathway, which produces NADPH and the essential nucleotide component ribose-5-phosphate. Here, we describe riboneogenesis, a thermodynamically driven pathway that converts glycolytic intermediates into ribose-5-phosphate without production of NADPH. Riboneogenesis begins with synthesis, by the combined action of transketolase and aldolase, of the seven-carbon bisphosphorylated sugar sedoheptulose-1,7-bisphosphate. In the pathway's committed step, sedoheptulose bisphosphate is hydrolyzed to sedoheptulose-7-phosphate by the enzyme sedoheptulose-1,7-bisphosphatase (SHB17), whose activity we identified based on metabolomic analysis of the corresponding knockout strain. The crystal structure of Shb17 in complex with sedoheptulose-1,7-bisphosphate reveals that the substrate binds in the closed furan form in the active site. Sedoheptulose-7-phosphate is ultimately converted by known enzymes of the nonoxidative pentose phosphate pathway to ribose-5-phosphate. Flux through SHB17 increases when ribose demand is high relative to demand for NADPH, including during ribosome biogenesis in metabolically synchronized yeast cells.
riboneogenesis
NCBI PubMed ID: 21663798Publication DOI: 10.1016/j.cell.2011.05.022Journal NLM ID: 0413066Publisher: Cambridge, MA: Cell Press
Correspondence: Rabinowitz JD
; Caudy AA
Institutions: Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, USA, Department of Chemical Engineering and Applied Chemistry, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Department of Chemistry, University of Tennessee, Knoxville, USA, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
Methods: crystallography, extraction, cell growth, LC-MS/MS, HPLC-MS, enzymatic assay
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Total list of corresponding CSDB IDs (permanent record IDs):
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