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Structure type: monomer ; 533 [M+Na]+
C₂₄H₃₀O₁₂
Compound class: iridoid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 11953
  Li YM, Jiang SH, Gao WY, Zhu DY "Iridoid glycosides from Scrophularia ningpoensis" - Phytochemistry 50(1) (1999) 101-104
  

  Three new minor iridoids were isolated from the roots of Scrophularia ningpoensis. They were elucidated as 8-O-feruloylharpagide, 8-O-(2-hydroxy-cinnamoyl)harpagide and 6-O-α-D-galactopyranosylharpagoside.

  Scrophulariaceae, iridoid glycosides, Scrophularia ningpoensis, 8-O-feruloylharpagide, 8-O-(2-hydroxycinnamoyl)harpagide, 6-O-α-D-galactopyranosylharpagoside

  Publication DOI: 10.1016/S0031-9422(98)00477-4
  Journal NLM ID: 0151434
  Publisher: Elsevier
  Institutions: State Key Laboratory of Drug Research of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200031, China
  Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, optical rotation measurement, TOCSY, HMBC, HMQC, COSY, HCl hydrolysis
  
   
  
  Scrophularia ningpoensis
  CSDB ID 64134 (all data & tools)

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Structure type: monomer
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 12052
  Capasso A, Saturnino P, Simone FD, Aquino R "Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro" - Phytotherapy Research 14(7) (2000) 538-540
  

  The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.

  guinea-pig ileum, Aristeguietia discolor, morphine, naloxone

  NCBI PubMed ID: 11054845
  Publication DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1
  Journal NLM ID: 8904486
  Publisher: Chichester: Wiley
  Correspondence: Capasso A
  Institutions: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
  Methods: biological assays
  
   
  
  Aristeguietia discolor
  CSDB ID 65008 (all data & tools)

Show legend Show as text

Structure type: monomer
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 12052
  Capasso A, Saturnino P, Simone FD, Aquino R "Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro" - Phytotherapy Research 14(7) (2000) 538-540
  

  The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.

  guinea-pig ileum, Aristeguietia discolor, morphine, naloxone

  NCBI PubMed ID: 11054845
  Publication DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1
  Journal NLM ID: 8904486
  Publisher: Chichester: Wiley
  Correspondence: Capasso A
  Institutions: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
  Methods: biological assays
  
   
  
  Aristeguietia discolor
  CSDB ID 65009 (all data & tools)