Found 40 structures.
Displayed structures from 1 to 15
Next 15 structure(s)
Expand all compounds
Collapse all compounds
Show all as text (SweetDB notation)
Show all graphically (SNFG notation)
1. Compound ID: 579
Structure type: oligomer
Trivial name: core-lipid A region
Contained glycoepitopes: IEDB_136906,IEDB_137472,IEDB_140529,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_151528,IEDB_167069,IEDB_190606,IEDB_983931,SB_192,SB_7
The structure is contained in the following publication(s):
- Article ID: 174
Vinogradov E, Sidorczyk Z "The structure of the core part of Proteus penneri strain 16 lipopolysaccharide" -
Carbohydrate Research 326(3) (2000) 185-193
The structure of the carbohydrate backbone of the lipid A-core region of the lipopolysaccharide (LPS) from Proteus penneri strain 16 was determined using NMR and chemical analysis of the core oligosaccharide, obtained by mild acid hydrolysis of the LPS, and of the products of alkaline deacylation of the LPS: formula [see text]. Incomplete substitution is indicated by bold italics. All sugars are in the pyranose form, α-Hep is the residue of L-glycero-α-D-manno-Hep, α-DD-Hep is the residue of D-glycero-α-D-manno-Hep, Bu is the (R)-3-hydroxybutyryl residue.
Lipopolysaccharide, LPS, structure, core, strain, Proteus, Proteus penneri
NCBI PubMed ID: 10903028Publication DOI: 10.1016/S0008-6215(99)00304-3Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: evguenii.vinogradov@nrc.ca
Institutions: Carlsberg Laboratory, Department of Chemistry. Gamle Carlsberg Vej 10, DK- 2500 Valby, Copenhagen, Denmark, Institute of Microbiology and Immunology, Uni6ersity of Lodz, 90- 237 Lodz, Banacha 12: 16, Poland
Methods: NMR-2D, NMR, chemical analysis
Expand this compound
Collapse this compound
2. Compound ID: 2405
Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 830
Isshiki Y, Matsuura M, Dejsirilert S, Ezaki T, Kawahara K "Separation of 6-deoxy-heptane from a smooth-type lipopolysaccharide preparation of Burkholderia pseudomallei" -
FEMS Microbiology Reviews 199 (2001) 21-25
Smooth-type lipopolysaccharide (LPS) of Burkholderia pseudomallei has been reported to contain two kinds of O-antigenic polysaccharides, a 1,3-linked homopolymer of 6-deoxy-heptose and a polymer with a repeating unit of →3)-glucose-(1→3)-6-deoxytalose-(1→ with O-acetyl or O-methyl modifications. A LPS preparation containing these two polysaccharides was separated by gelpermeation chromatography in this study. Chemical analysis of the separated fractions revealed the 6-deoxy-heptane to be a polysaccharide without a lipid portion and the polymer of glucose and 6-deoxy-talose to be an O-antigenic polysaccharide of the LPS. This result was further supported by the assay of these polysaccharide molecules for macrophage activation activity. The 6-deoxy-heptane showed no macrophage activation, indicating that this polysaccharide was not the LPS, but one of the capsular polysaccharides of B. pseudomallei.
Lipopolysaccharide, structure, Burkholderia, Burkholderia pseudomallei, chemical, isolation, preparation, separation, melioidosis
NCBI PubMed ID: 11356562Journal NLM ID: 8902526Publisher: Oxford University Press
Correspondence: kawahara-k@kitasato.or.jp
Institutions: Department of Bacteriology, The Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan, Department of Microbiology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Tochigi 329-0498, Japan, National Institute of Health, Nonthaburi 11000, Thailand, Department of Microbiology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan
Methods: SDS-PAGE, GLC, GPC
Expand this compound
Collapse this compound
3. Compound ID: 2841
|
a-Kdop-(2-4)-+
|
b-D-GlcpA6NH2-(1-3)-b-D-Glc-(1-4)-+ | P-4)-+
| | |
3HO2,3MePro-5-oxo-(1-3)-b-D-Quip3N-(1-2)-a-L-Rhap-(1-4)-a-D-GalpA6NH2-(1-6)-a-D-Galp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P |
Show graphically |
Structure type: oligomer
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130650,IEDB_130659,IEDB_135394,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_150908,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_225177,IEDB_423153,IEDB_885823,IEDB_983931,SB_192,SB_7
The structure is contained in the following publication(s):
- Article ID: 1001
Molinaro A, De Castro C, Lanzetta R, Parrilli M, Raio A, Zoina A "Structural elucidation of a novel core oligosaccharide backbone of the lipopolysaccharide from the new bacterial species Agrobacterium larrymoorei" -
Carbohydrate Research 338(23) (2003) 2721-2730
Agrobacterium larrymoorei is a Gram-negative phytopathogenic bacterium, which produces tumours on Ficus benjamina plants and differs from other Agrobacteria both genetically and biochemically. The lipopolysaccharide (LPS) plays an important role in the pathogenesis of Agrobacteria. The present paper is the first report on the molecular primary structure of the core region of an Agrobacterium LPS. The following structure of the core and lipid A carbohydrate backbone of an R-form LPS of A. larrymoorei was determined by chemical degradations and 1D and 2D NMR spectroscopy: [carbohydrate structure: see text] All sugars are α-D-pyranoses if not stated otherwise, Kdo is 3-deoxy-D-manno-oct-2-ulosonic acid, Qui3NAcyl is 3,6-dideoxy-3-(3-hydroxy-2,3-dimethyl-5-oxoprolylamino)glucose, GlcAN and GalAN are amides of GlcA and GalA.
core oligosaccharide, Phytopathogenic bacteria, R-form lipopolysaccharide, 3-Hydroxy-2, 3-dimethyl-5-oxoprolyl group, Agrobacterium larrymoorei
NCBI PubMed ID: 14670730Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: molinaro@unina.it
Institutions: Dipartimento di Chimica Organica e Boichimica, Univesita di Napoli Rederico II,Complesso Universitario Monte Sant Angelo, Napoli, Italy
Methods: NMR
Expand this compound
Collapse this compound
4. Compound ID: 2842
|
a-Kdop-(2-4)-+
|
b-L-4dthrHexp4enA-(1-6)-+ | P-4)-+
| | |
b-D-GlcpA-(1-3)-b-D-Glc-(1-4)-a-D-Galp-(1-5)-a-Kdop-(2-6)-b-D-GlcpN-(1-6)-a-D-GlcpN-(1-P |
Show graphically |
Structure type: oligomer
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130650,IEDB_130659,IEDB_135394,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_150908,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_423153,IEDB_983931,SB_192,SB_7
The structure is contained in the following publication(s):
- Article ID: 1001
Molinaro A, De Castro C, Lanzetta R, Parrilli M, Raio A, Zoina A "Structural elucidation of a novel core oligosaccharide backbone of the lipopolysaccharide from the new bacterial species Agrobacterium larrymoorei" -
Carbohydrate Research 338(23) (2003) 2721-2730
Agrobacterium larrymoorei is a Gram-negative phytopathogenic bacterium, which produces tumours on Ficus benjamina plants and differs from other Agrobacteria both genetically and biochemically. The lipopolysaccharide (LPS) plays an important role in the pathogenesis of Agrobacteria. The present paper is the first report on the molecular primary structure of the core region of an Agrobacterium LPS. The following structure of the core and lipid A carbohydrate backbone of an R-form LPS of A. larrymoorei was determined by chemical degradations and 1D and 2D NMR spectroscopy: [carbohydrate structure: see text] All sugars are α-D-pyranoses if not stated otherwise, Kdo is 3-deoxy-D-manno-oct-2-ulosonic acid, Qui3NAcyl is 3,6-dideoxy-3-(3-hydroxy-2,3-dimethyl-5-oxoprolylamino)glucose, GlcAN and GalAN are amides of GlcA and GalA.
core oligosaccharide, Phytopathogenic bacteria, R-form lipopolysaccharide, 3-Hydroxy-2, 3-dimethyl-5-oxoprolyl group, Agrobacterium larrymoorei
NCBI PubMed ID: 14670730Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: molinaro@unina.it
Institutions: Dipartimento di Chimica Organica e Boichimica, Univesita di Napoli Rederico II,Complesso Universitario Monte Sant Angelo, Napoli, Italy
Methods: NMR
Expand this compound
Collapse this compound
5. Compound ID: 2843
|
b-D-GlcpA6NH2-(1-3)-b-D-Glc-(1-4)-+
|
3HO2,3MePro-5-oxo-(1-3)-b-Quip3N-(1-2)-a-L-Rhap-(1-4)-a-D-GalpA6NH2-(1-6)-a-D-Galp-(1-5)-Kdo |
Show graphically |
Structure type: oligomer
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_115136,IEDB_130650,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_151528,IEDB_190606,IEDB_225177,IEDB_423153,IEDB_885823,IEDB_983931,SB_192,SB_7
The structure is contained in the following publication(s):
- Article ID: 1001
Molinaro A, De Castro C, Lanzetta R, Parrilli M, Raio A, Zoina A "Structural elucidation of a novel core oligosaccharide backbone of the lipopolysaccharide from the new bacterial species Agrobacterium larrymoorei" -
Carbohydrate Research 338(23) (2003) 2721-2730
Agrobacterium larrymoorei is a Gram-negative phytopathogenic bacterium, which produces tumours on Ficus benjamina plants and differs from other Agrobacteria both genetically and biochemically. The lipopolysaccharide (LPS) plays an important role in the pathogenesis of Agrobacteria. The present paper is the first report on the molecular primary structure of the core region of an Agrobacterium LPS. The following structure of the core and lipid A carbohydrate backbone of an R-form LPS of A. larrymoorei was determined by chemical degradations and 1D and 2D NMR spectroscopy: [carbohydrate structure: see text] All sugars are α-D-pyranoses if not stated otherwise, Kdo is 3-deoxy-D-manno-oct-2-ulosonic acid, Qui3NAcyl is 3,6-dideoxy-3-(3-hydroxy-2,3-dimethyl-5-oxoprolylamino)glucose, GlcAN and GalAN are amides of GlcA and GalA.
core oligosaccharide, Phytopathogenic bacteria, R-form lipopolysaccharide, 3-Hydroxy-2, 3-dimethyl-5-oxoprolyl group, Agrobacterium larrymoorei
NCBI PubMed ID: 14670730Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: molinaro@unina.it
Institutions: Dipartimento di Chimica Organica e Boichimica, Univesita di Napoli Rederico II,Complesso Universitario Monte Sant Angelo, Napoli, Italy
Methods: NMR
Expand this compound
Collapse this compound
6. Compound ID: 2916
|
b-D-Fruf-(2-6)-b-D-Glc-(1-4)-+
|
L-gro-a-D-manHepp-(1-6)-+ | EtN-(1--P--7)--+
| | |
a-D-GlcN-(1-7)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHep-(1-5)-a-Kdop-(2--/lipid A/
| |
a-D-Glc-(1-6)-+ P-4)-+ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 1048
Nesper J, Kraiss A, Schild S, Blabeta J, Klose KE, Bockemuhl J, Reidl J "Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster" -
Infection and Immunity 70(5) (2002) 2419-2433
We identified five different putative wav gene cluster types, which are responsible for the synthesis of the core oligosaccharide (OS) region of Vibrio cholerae lipopolysaccharide. Preliminary evidence that the genes encoded by this cluster are involved in core OS biosynthesis came from analysis of the recently released O1 El Tor V. cholerae genome sequence and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of O1 El Tor mutant strains defective in three genes (waaF, waaL, and wavB). Investigations of 38 different V. cholerae strains by Southern blotting, PCR, and sequencing analyses showed that the O1 El Tor wav gene cluster type is prevalent among clinical isolates of different serogroups associated with cholera and environmental O1 strains. In contrast, we found differences in the wav gene contents of 19 unrelated non-O1, non-O139 environmental and human isolates not associated with cholera. These strains contained four new wav gene cluster types that differ from each other in distinct gene loci, providing evidence for horizontal transfer of wav genes and for limited structural diversity of the core OS among V. cholerae isolates. Our results show genetic diversity in the core OS biosynthesis gene cluster and predominance of the type 1 wav gene locus in strains associated with clinical cholera, suggesting that a specific core OS structure could contribute to V. cholerae virulence
Lipopolysaccharide, biosynthesis, genetic, synthesis, transfer, LPS, oligosaccharide, structure, core, blotting, clinical, gene, human, isolate, PCR, strain, structural, virulence, analysis, locus, type, core oligosaccharide, lipopolysaccharide core, lipopolysaccharide core oligosaccharide, cluster, gene cluster, specific, mutant, serogroup, putative, region, sequencing, sequence, difference, Vibrio, content, Vibrio cholerae, genome, gel electrophoresis, cholera, genetic diversity, diversity, electrophoresis, gel, environmental
NCBI PubMed ID: 11953379Journal NLM ID: 0246127Publisher: American Society for Microbiology
Correspondence: oachim.reidl@mail.uni-wuerzburg.de
Institutions: Zentrum fur Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany, Hygiene Institut Hamburg, Hamburg, Germany. University of Texas Health Science Center, San Antonio, Texas 78284-7758
Methods: genetic methods
Expand this compound
Collapse this compound
7. Compound ID: 2959
|
a-D-GlcN-(1-7)-+ b-D-Sedf-(2-6)-b-D-Glc-(1-4)-+ P-4)-+
| | |
b-D-Sedf-(2-3)-b-D-Gal-(1-3)-L-gro-a-D-manHepp-(1-2)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2--/lipid A/
|
a-D-Glc-(1-6)-+ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_136044,IEDB_136095,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 1048
Nesper J, Kraiss A, Schild S, Blabeta J, Klose KE, Bockemuhl J, Reidl J "Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster" -
Infection and Immunity 70(5) (2002) 2419-2433
We identified five different putative wav gene cluster types, which are responsible for the synthesis of the core oligosaccharide (OS) region of Vibrio cholerae lipopolysaccharide. Preliminary evidence that the genes encoded by this cluster are involved in core OS biosynthesis came from analysis of the recently released O1 El Tor V. cholerae genome sequence and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of O1 El Tor mutant strains defective in three genes (waaF, waaL, and wavB). Investigations of 38 different V. cholerae strains by Southern blotting, PCR, and sequencing analyses showed that the O1 El Tor wav gene cluster type is prevalent among clinical isolates of different serogroups associated with cholera and environmental O1 strains. In contrast, we found differences in the wav gene contents of 19 unrelated non-O1, non-O139 environmental and human isolates not associated with cholera. These strains contained four new wav gene cluster types that differ from each other in distinct gene loci, providing evidence for horizontal transfer of wav genes and for limited structural diversity of the core OS among V. cholerae isolates. Our results show genetic diversity in the core OS biosynthesis gene cluster and predominance of the type 1 wav gene locus in strains associated with clinical cholera, suggesting that a specific core OS structure could contribute to V. cholerae virulence
Lipopolysaccharide, biosynthesis, genetic, synthesis, transfer, LPS, oligosaccharide, structure, core, blotting, clinical, gene, human, isolate, PCR, strain, structural, virulence, analysis, locus, type, core oligosaccharide, lipopolysaccharide core, lipopolysaccharide core oligosaccharide, cluster, gene cluster, specific, mutant, serogroup, putative, region, sequencing, sequence, difference, Vibrio, content, Vibrio cholerae, genome, gel electrophoresis, cholera, genetic diversity, diversity, electrophoresis, gel, environmental
NCBI PubMed ID: 11953379Journal NLM ID: 0246127Publisher: American Society for Microbiology
Correspondence: oachim.reidl@mail.uni-wuerzburg.de
Institutions: Zentrum fur Infektionsforschung, Universitat Wurzburg, Wurzburg, Germany, Hygiene Institut Hamburg, Hamburg, Germany. University of Texas Health Science Center, San Antonio, Texas 78284-7758
Methods: genetic methods
Expand this compound
Collapse this compound
8. Compound ID: 3544
|
Lac-(2-4)-b-D-GlcpA-(1-6)-a-D-Glcp-(1-4)-+
|
-4)-b-D-Glc-(1-3)-b-D-Galp6Ac-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_136044,IEDB_137472,IEDB_140630,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_190606,IEDB_423153,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_6,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 1307
Zamze S, Martinez-Pomares L, Jones H, Taylor PR, Stillion RJ, Gordon S, Wong SY "Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor" -
Journal of Biological Chemistry 277(44) (2002) 41613-41623
The in vitro binding of the macrophage mannose receptor to a range of different bacterial polysaccharides was investigated. The receptor was shown to bind to purified capsular polysaccharides from Streptococcus pneumoniae and to the lipopolysaccharides, but not capsular polysaccharides, from Klebsiella pneumoniae. Binding was Ca(2+)- dependent and inhibitable with d-mannose. A fusion protein of the mannose receptor containing carbohydrate recognition domains 4-7 and a full-length soluble form of the mannose receptor containing all domains external to the transmembrane region both displayed very similar binding specificities toward bacterial polysaccharides, suggesting that domains 4-7 are sufficient for recognition of these structures. Surprisingly, no direct correlation could be made between polysaccharide structure and binding to the mannose receptor, suggesting that polysaccharide conformation may play an important role in recognition. The full-length soluble form of the mannose receptor was able to bind simultaneously both polysaccharide via the carbohydrate recognition domains and sulfated oligosaccharide via the cysteine-rich domain. The possible involvement of the mannose receptor, either cell surface or soluble, in the innate and adaptive immune responses to bacterial polysaccharides is discussed
lipopolysaccharides, structure, Streptococcus pneumoniae, capsular polysaccharides, recognition, Klebsiella pneumoniae, Mannose, macrophage, receptor
NCBI PubMed ID: 12196537Journal NLM ID: 2985121RPublisher: Baltimore, MD: American Society for Biochemistry and Molecular Biology
Correspondence: susanne.zamze@jenner.ac.uk
Institutions: Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom and the Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Expand this compound
Collapse this compound
9. Compound ID: 3854
Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115015,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_142489,IEDB_146664,IEDB_149135,IEDB_151528,IEDB_190606,IEDB_983931,SB_7,SB_86
The structure is contained in the following publication(s):
- Article ID: 1453
Corsaro MM, De Castro C, Molinaro A, Parrilli M "Structure of lipopolysaccharides from phytopathogenic Gram-negative bacteria" -
Book: Recent Research Developments in Phytochemistry (2001) Vol. 5, 119-138
This review collects the structural data of lipopolysaccharide components arising from all phytopathogenic bacteria so far investigated. The structural approaches and the main biological role of these macromolecules are also reported.
Lipopolysaccharide, lipopolysaccharides, structure, core, lipid A, O-polysaccharide, gram negative bacteria
WWW link: https://books.google.ru/books/about/Recent_Research_Developments_in_Phytoche.html?id=5CJacgAACAAJ&redir_esc=yPublisher: Research Signpost, Trivandrum, India
Editors: Pandalai SG
Institutions: Dipartimento di Chimica Organica e Biochimica, Complesso Universitario Monte S.Angelo Via Cintia, 4, 80126 Napoli, Italy
- Article ID: 1778
Knirel YA, Kochetkov NK "The structure of lipopolysaccharides of gram-negative bacteria. III. The structure of O-antigens: A review" -
Biochemistry (Moscow) 59(12) (1994) 1325-1383
This review summarizes data on the composition and structure of the O-antigens, the polysaccharide chains of the outer-membrane lipopolysaccharides (LPS) of Gram-negative bacteria defining the immunospecificity of these microbial cells. Special reference is given to some structural features of the O-antigens, such as the presence of unique monosaccharides and noncarbohydrate components, masked regularity, and the occurrence in one microorganism of LPS with structurally different polysaccharide chains. Antigenic relationships between microorganisms belonging to different taxonomic groups are discussed.
structure, O-antigen, chemical composition, bacterial lipopolysaccharides, Salmonella livingstone C1
NCBI PubMed ID: 7533007Journal NLM ID: 0376536Publisher: Nauka/Interperiodica
Institutions: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
- Article ID: 2412
Ray TC, Smith ARW, Wait R, Hignett RC "Structure of the sidechain of lipopolysaccharide from Erwinia amylovora T" -
European Journal of Biochemistry 170 (1987) 357-361
Journal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
Methods: 13C NMR, 1H NMR
Expand this compound
Collapse this compound
10. Compound ID: 3936
|
b-D-Glc-(1-4)-+ P-4)-+
| |
a-D-GlcN-(1-7)-L-gro-a-D-manHep-(1-2)-L-gro-a-D-manHep-(1-3)-L-gro-a-D-manHep-(1-5)-a-Kdo-(2--/lipid A/
|
a-D-Glc-(1-6)-+ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Contained glycoepitopes: IEDB_130650,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 1463
Izquierdo L, Merino S, Coderch N, Regue M, Tomas JM "The wavB gene of Vibrio cholerae and the waaE of Klebsiella pneumoniae codify for a b-1,4-glucosyltransferase involved in the transfer of a glucose residue to the L-glycero-D-manno-heptose I in the lipopolysaccharide inner core" -
FEMS Microbiology Letters 216(2) (2002) 211-216
Vibrio cholerae WavB protein showed some similarity to WaaE of Klebsiella pneumoniae and Serratia marcescens. From previous data obtained by us and by chemical analyses of a K. pneumoniae non-polar waaE mutant from strain 889 (08:K69), its lipopolysaccharide (LPS) core structure has recently been elucidated. We demonstrated that WaaE is a β-1,4-glucosyltransferase involved in the transfer of a glucose residue to the L-glycero-D-manno-heptose I in the LPS inner core. Complementation of this K. pneumoniae non-polar waaE mutant with gene wavB obtained, either from V. cholerae or V. mimicus, showed a full complementation either by chemical studies or by a biological test (susceptibility to non-immune serum). The V. cholerae wavB gene is located in a putative core oligosaccharide (OS) gene cluster and the V. cholerae OS core structure showed the same β-1,4-glucose residue attached to Hep I as is observed for the K. pneumoniae 889 OS core structure. No other glucose residue is found in the ligosaccharide core structure of K. pneumoniae 889. We concluded that WavB protein is able to perform the same function as WaaE.
Lipopolysaccharide, complementation, transfer, L-glycero-D-manno-heptose, LPS, structure, core, gene, strain, protein, mutant, Klebsiella, Serratia marcescens, chemical, inner core, Vibrio, glucose, Vibrio cholerae, Klebsiella pneumoniae, Serratia, similarity
NCBI PubMed ID: 12435504Journal NLM ID: 7705721Publisher: Blackwell Publishing
Correspondence: juant@porthos.bio.ub.es
Institutions: Departamento de Microbiologi'a, Facultad de Biologi'a, Universidad de Barcelona, Diagonal 645, 08071, Barcelona, Spain, Departamento de Microbiologi'a y Parasitologi'a Sanitarias, Divisio'n de Ciencias de la Salud, Facultad de Farmacia, Universidad de Barcelona, Av. Joan XXIII s/n, Barcelona 08028, Spain
Methods: GLC-MS, DNA sequencing, SDS-PAGE
Expand this compound
Collapse this compound
11. Compound ID: 3937
|
L-gro-a-D-manHep-(1-7)-+ b-D-Glc-(1-4)-+ a-Kdo-(2-4)-+
| | |
a-Kdo-(2-6)-a-D-GlcN-(1-4)-a-D-GalA-(1-3)-L-gro-a-D-manHep-(1-3)-L-gro-a-D-manHep-(1-5)-a-Kdo-(2--/lipid A/ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_130670,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151531,IEDB_2189047,IEDB_226811,IEDB_983931,SB_192
The structure is contained in the following publication(s):
- Article ID: 1463
Izquierdo L, Merino S, Coderch N, Regue M, Tomas JM "The wavB gene of Vibrio cholerae and the waaE of Klebsiella pneumoniae codify for a b-1,4-glucosyltransferase involved in the transfer of a glucose residue to the L-glycero-D-manno-heptose I in the lipopolysaccharide inner core" -
FEMS Microbiology Letters 216(2) (2002) 211-216
Vibrio cholerae WavB protein showed some similarity to WaaE of Klebsiella pneumoniae and Serratia marcescens. From previous data obtained by us and by chemical analyses of a K. pneumoniae non-polar waaE mutant from strain 889 (08:K69), its lipopolysaccharide (LPS) core structure has recently been elucidated. We demonstrated that WaaE is a β-1,4-glucosyltransferase involved in the transfer of a glucose residue to the L-glycero-D-manno-heptose I in the LPS inner core. Complementation of this K. pneumoniae non-polar waaE mutant with gene wavB obtained, either from V. cholerae or V. mimicus, showed a full complementation either by chemical studies or by a biological test (susceptibility to non-immune serum). The V. cholerae wavB gene is located in a putative core oligosaccharide (OS) gene cluster and the V. cholerae OS core structure showed the same β-1,4-glucose residue attached to Hep I as is observed for the K. pneumoniae 889 OS core structure. No other glucose residue is found in the ligosaccharide core structure of K. pneumoniae 889. We concluded that WavB protein is able to perform the same function as WaaE.
Lipopolysaccharide, complementation, transfer, L-glycero-D-manno-heptose, LPS, structure, core, gene, strain, protein, mutant, Klebsiella, Serratia marcescens, chemical, inner core, Vibrio, glucose, Vibrio cholerae, Klebsiella pneumoniae, Serratia, similarity
NCBI PubMed ID: 12435504Journal NLM ID: 7705721Publisher: Blackwell Publishing
Correspondence: juant@porthos.bio.ub.es
Institutions: Departamento de Microbiologi'a, Facultad de Biologi'a, Universidad de Barcelona, Diagonal 645, 08071, Barcelona, Spain, Departamento de Microbiologi'a y Parasitologi'a Sanitarias, Divisio'n de Ciencias de la Salud, Facultad de Farmacia, Universidad de Barcelona, Av. Joan XXIII s/n, Barcelona 08028, Spain
Methods: GLC-MS, DNA sequencing, SDS-PAGE
Expand this compound
Collapse this compound
12. Compound ID: 5074
Structure type: oligomer
Compound class: CPS
Contained glycoepitopes: IEDB_115136,IEDB_130701,IEDB_140630,IEDB_142488,IEDB_144983,IEDB_146664,IEDB_152206,IEDB_164174,IEDB_423153,IEDB_983930,IEDB_983931,SB_192,SB_197,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 2014
Dutton GGS, Karunaratne DN "Structural investigation of the capsular polysaccharide of Klebsiella serotype K67" -
Carbohydrate Research 119 (1983) 157-169
The determination of the structure of the capsular polysaccharide from Klebsiella K67 involved the use of methylation, periodate oxidation, partial hydrolysis, and β-elimination. The nature of the anomeric linkages was established by using 1H- and 13C-n.m.r. spectroscopy, and was further confirmed by chromic acid oxidation of the fully acetylated polysaccharide. The polysaccharide was found to have the heptasaccharide repeating unit shown. A structure having a branched side-chain is unique in this series of capsular polysaccharides.
capsular polysaccharide, Klebsiella K67
Publication DOI: 10.1016/0008-6215(83)84054-3Journal NLM ID: 0043535Publisher: Elsevier
Institutions: Department of Chemistry, The University of British Columbia, Vancouver, B.C. V6T 1Y6 Canada
Methods: 13C NMR, 1H NMR, methylation, GLC-MS, partial acid hydrolysis, sugar analysis, GLC, Smith degradation, paper chromatography, GPC, ion-exchange chromatography, uronic acid degradation
Expand this compound
Collapse this compound
13. Compound ID: 6387
|
b-D-Galp-(1-4)-+ ?%b-D-Glc-(1-3)-+ a-D-Glcp-(1--P--6)--+
| | |
a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--P--6)--{{{-b-D-Galp-(1-4)-a-D-Manp-(1--P--6)--}}}/n=30/-a-D-Galp-(1-6)-a-D-Galp-(1-3)-b-D-Galf-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-L-myoIno-(1--P--3)--Gro1ALK |
Show graphically |
Structure type: oligomer
Trivial name: GPI-anchor
Compound class: lipophosphoglycan
Contained glycoepitopes: IEDB_130701,IEDB_134623,IEDB_134624,IEDB_136044,IEDB_136095,IEDB_136100,IEDB_136104,IEDB_136906,IEDB_137472,IEDB_140116,IEDB_141794,IEDB_141807,IEDB_141830,IEDB_142488,IEDB_143632,IEDB_144983,IEDB_144996,IEDB_144998,IEDB_145002,IEDB_146664,IEDB_151528,IEDB_151531,IEDB_152206,IEDB_164174,IEDB_189518,IEDB_190606,IEDB_433717,IEDB_474450,IEDB_983930,IEDB_983931,SB_136,SB_163,SB_165,SB_166,SB_187,SB_192,SB_195,SB_196,SB_197,SB_44,SB_67,SB_7,SB_72,SB_88
The structure is contained in the following publication(s):
- Article ID: 1736
McConville MJ, Ferguson MAJ "The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes" -
Biochemical Journal 294 (1993) 305-324
No abstract available
NCBI PubMed ID: 8373346Publication DOI: 10.1042/bj2940305Journal NLM ID: 2984726RPublisher: London, UK : Published by Portland Press on behalf of the Biochemical Society
Institutions: Department of Biochemistry, University of Dundee, U.K., Department of Biochemistry, University of Dundee, U.K
Expand this compound
Collapse this compound
14. Compound ID: 7439
|
b-D-GalpNAc-(1-3)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Glc-(1-4)-+
|
a-D-GlcpNAc-(1-2)-+ |
| |
EtN-(1--P--4)--+ | | a-Kdop-(2-4)-+
| | | |
b-D-GalpNAc-(1-3)-b-D-Galp-(1-4)-b-D-Galp-(1-4)-a-D-Glcp-(1-3)-L-gro-a-D-manHepp-(1-3)-L-gro-a-D-manHepp-(1-5)-a-Kdop-(2--/lipid A/
|
EtN-(1--P--7)--+ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Compound class: LOS
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130646,IEDB_130648,IEDB_130650,IEDB_130659,IEDB_130697,IEDB_135813,IEDB_136024,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_137776,IEDB_138712,IEDB_1391966,IEDB_140087,IEDB_140088,IEDB_140089,IEDB_140090,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_149144,IEDB_151531,IEDB_190606,IEDB_2189047,IEDB_221845,IEDB_226300,IEDB_418762,IEDB_418764,IEDB_418767,IEDB_418769,IEDB_419429,IEDB_419430,IEDB_983931,SB_145,SB_165,SB_166,SB_173,SB_187,SB_192,SB_195,SB_21,SB_30,SB_6,SB_7,SB_88
The structure is contained in the following publication(s):
- Article ID: 3360
Patrone JB, Stein DC "Effect of gonococcal lipooligosaccharide variation on human monocytic cytokine profile" -
BMC Microbiology 7 (2007) 7
BACKGROUND: Neisseria gonorrhoeae is an obligate human pathogen that causes significant worldwide morbidity. N. gonorrhoeae expresses lipooligosaccharide (LOS), a phase variable molecule that plays an important role during pathogenesis of the organism. Alteration in the structure of gonococcal LOS correlates with altered disease presentation. In addition, LOS sialylation occurs readily in vivo, though the role of this sialylation during disease is unknown. RESULTS: Challenge of human monocytes with purified LOS preparations isolated from strains expressing distinct structurally defined LOSs resulted in identical production of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-12 (IL-12). Similar results were seen when monocytes were challenged with either live or gentamicin-killed whole cell gonococcal variants expressing these LOS structures, although greater cytokine production was observed in comparison with challenge by purified LOS. Challenge of a human primary monocyte model with distinct LOS variants resulted in similar production of TNF-α, IL-12, interleukin-10 (IL-10), and interleukin-8 (IL-8). A cytokine array was employed to allow measurement of a broad range of cytokines in samples challenge with gonococcal LOS variants as well as variants expressing sialylated LOS. Challenge of primary monocytes with sialylated gonococci was shown to elicit the production of more MCP-2 (monocyte chemoattractant protein-2) in comparison with challenge by unsialylated gonococci. CONCLUSION: We demonstrated that while alterations in the carbohydrate moiety of LOS do not impact the production of most cytokines by human monocytes, whole-cell bacterial challenge is more stimulatory than challenge with purified LOS, implying that other gonococcal cell surface antigens are important for the elicitation of cytokines. Challenge with gonococci expressing sialylated LOS resulted in elicitation of more of the chemokine MCP-2 from challenged cells in comparison with gonococci expressing unsialylated LOS. As MCP-2 is an important chemoattractant, this indicates that in vivo sialylation may play an important role during the pathogenesis of N. gonorrhoeae
Neisseria gonorrhoeae, Gonococcal Infection, cytokine Array, primary Human Monocyte, primary Monocyte
NCBI PubMed ID: 17257430Publication DOI: 10.1186/1471-2180-7-7Journal NLM ID: 100966981Publisher: Biomed Central
Correspondence: julia_patrone@yahoo.com
Institutions: Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
Methods: SDS-PAGE, serological methods
Expand this compound
Collapse this compound
15. Compound ID: 7772
Structure type: oligomer
Contained glycoepitopes: IEDB_115136,IEDB_130701,IEDB_140630,IEDB_142488,IEDB_144983,IEDB_146664,IEDB_152206,IEDB_164174,IEDB_423153,IEDB_983930,IEDB_983931,SB_192,SB_197,SB_44,SB_67,SB_72
The structure is contained in the following publication(s):
- Article ID: 3462
Dobruchowska JM, Gerwig GJ, Babuchowski A, Kamerling JP "Structural studies on exopolysaccharides produced by three different propionibacteria strains" -
Carbohydrate Research 343(4) (2008) 726-745
The exopolysaccharides produced by three propionibacteria strains, Propionibacterium freudenreichii 109, Propionibacterium freudenreichii 111, and Propionibacterium thoenii 126, grown on whey-based media, were found to be charged heteropolymers, composed of d-glucose, d-mannose, and d-glucuronic acid in molar ratios of 2:2:1. By means of methylation analysis, mass spectrometry, partial acid hydrolysis, and 1D/2D NMR ((1)H and (13)C) studies, it was determined that all three exopolysaccharides contain the same branched, pentasaccharide repeating unit:
NMR, exopolysaccharide, structural analysis, EPS, MS, Propionibacterium
NCBI PubMed ID: 18184608Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: j.p.kamerling@uu.nl
Institutions: Bijvoet Center, Department of Bio-Organic Chemistry, Utrecht University, Utrecht, The Netherlands, Chair of Food Biotechnology, University of Warmia and Mazury, Heweliusza 1, 10-957 Olsztyn, Poland
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, GLC-EI-MS, partial acid hydrolysis, sugar analysis, GLC, MALDI-TOF MS
Expand this compound
Collapse this compound
Next 15 structure(s)
Total list of structure IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (permanent record IDs):
Execution: 1 sec