Taxonomic group: bacteria / Proteobacteria, Proteobacteria, Proteobacteria, Firmicutes
(Phylum: Proteobacteria, Proteobacteria, Proteobacteria, Firmicutes)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
];
infection due to Yersinia pestis [ICD11:
XN6QS ];
infection due to Staphylococcus epidermidis [ICD11:
XN8KJ ]
NCBI PubMed ID: 15601723Journal NLM ID: 2985120RPublisher: American Society for Microbiology
Institutions: Department of Microbiology and Immunology, Emory University School of Medicine, 3105 Rollins Research Center, 1510 Clifton Rd. N.E., Atlanta, GA 30322, USA
Polymeric β-1,6-N-acetyl-D-glucosamine (poly-β-1,6-GlcNAc) has been implicated as an Escherichia coli and Staphylococcus epidermidis biofilm adhesin, the formation of which requires the pgaABCD and icaABCD loci, respectively. Enzymatic hydrolysis of poly-β-1,6-GlcNAc, demonstrated for the first time by chromatography and mass spectrometry, disrupts biofilm formation by these species and by Yersinia pestis and Pseudomonas fluorescens, which possess pgaABCD homologues
Bacterial, metabolism, microbiology, Non-U.S.Gov't, Pseudomonas, Research, Escherichia, Escherichia coli, immunology, hydrolysis, spectrometry, mass spectrometry, enzymatic, medicine, formation, Staphylococcus, Pseudomonas fluorescens, time, chromatography, operon, species, adhesin, depolymerization, Yersinia, Actinobacillus actinomycetemcomitans, Bacterial Adhesion, biofilms, U.S.Gov't, PDF, Staphylococcus epidermidis, Biofilm, enzymology, Yersinia pestis, physiology, P.H.S., enzymatic hydrolysis, Acetylglucosamine, β-N-Acetylhexosaminidase, Research Support
Structure type: homopolymer
Location inside paper: abstract
Trivial name: poly-β-1,6-GlcNAc (PGA), biofilm, poly-b-(1-6)-N-acetyl-D-glucosamine (PNAG), poly-β-N-acetyl-glucosamine (PNAG), PNAG, poly-N-acetylglucosamine, PNAG
Compound class: CPS, EPS, O-polysaccharide, glucan, polysaccharide
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_753248
Methods: MS, chromatography
Biological activity: biofilm formation
Comments, role: exocellular polysaccharide, biofilm formation
NCBI Taxonomy refs (TaxIDs): 562,
632,
294,
1282Reference(s) to other database(s): GTC:G36952FI, GlycomeDB:
11210
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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