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Taxonomic group: bacteria / Firmicutes (Phylum: Firmicutes)
Host organism: Sus scrofa; Homo sapiens
Associated disease: septicemia [ICD11: MA15.Y

]; meningitis [ICD11: 1D01

]; infection due to Streptococcus suis [ICD11: XN5SE

]

NCBI PubMed ID: 33852172
Publication DOI: 10.1002/anie.202103990
Journal NLM ID: 0370543
Publisher: Weinheim: Wiley-VCH
Correspondence: Peter.Seeberger

mpikg.mpg.de
Institutions: Institute of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany, Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, 14476, Potsdam, Germany, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA

Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.

carbohydrates, Oligosaccharides, immunology, glycans, total synthesis, Streptococcus suis

Structure type: polymer chemical repeating unit
Location inside paper: p. 14680, Fig. 1, p. 14686, Fig. 5, serotype 9
Compound class: CPS
Contained glycoepitopes: IEDB_114708,IEDB_131186,IEDB_135818,IEDB_136044,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_151528,IEDB_167072,IEDB_190606,IEDB_225177,IEDB_742245,IEDB_885823,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88

Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ELISA, chemical synthesis, chemical methods, FTIR, HPLC, glycosylation, optical rotation measurement, glycan array analysis, HR-ESI-MS, flash chromatography

Related record ID(s): 10449, 10450, 10451, 10452, 10453, 10454, 10455, 10457, 10458, 10459, 10460, 10981
NCBI Taxonomy refs (TaxIDs): 1307
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

*O[C@H]([C@@H](O)CO)[C@H](O)[C@H](O)COP(=O)(O)O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]2C(=O)[C@@H](C)O[C@@H](O[C@H]3[C@@H](O)[C@H](*)O[C@@H](C)[C@@H]3O)[C@@H]2NC(C)=O)[C@@H]1O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize