Taxonomic group: protista / Euglenozoa
(Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: Life stage: trypomastigoteAssociated disease: Chagas disease [ICD11:
1F53 
, ICD11:
XN56V ];
infection due to Trypanosoma cruzi [ICD11:
XN56V ]
NCBI PubMed ID: 36083842Publication DOI: 10.1021/acsinfecdis.2c00370Journal NLM ID: 101654580Publisher: Washington, DC: American Chemical Society
Correspondence: R.M. de Lederkremer <lederk
qo.fcen.uba.ar>; C. Marino <cmarino
qo.fcen.uba.ar>
Institutions: CIHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
The α-gal epitope, which refers to the carbohydrate α-D-Galp-(1→3)-β-D-Galp-(1→4)-D-GlcNAc-R, was first described in the glycoconjugates of mammals other than humans. Evolution caused a mutation that resulted in the inactivation of the α-1,3-galactosyltransferase gene. For that reason, humans produce antibodies against α-D-Galp containing glycoproteins and glycolipids of other species. We summarize here the glycoconjugates with α-D-Galp structures in Trypanosoma, Leishmania, and Plasmodium pathogenic protozoa. These were identified in infective stages of Trypanosoma cruzi and in Plasmodium sporozoites. In Leishmania, α-D-Galp is linked differently in the glycans of glycoinositolphospholipids (GIPLs). Chemically synthesized neoglycoconjugates have been proposed as diagnostic tools and as antigens for vaccines. Several syntheses reported for the α-gal trisaccharide, also called the Galili epitope, and the glycans of GIPLs found in Leishmania, the preparation of neoglycoconjugates, and the studies in which they were involved are also included in this Review.
leishmania, Plasmodium, mucins, Trypanosoma, α-galactosyl, anti-α-Gal antibodies
Structure type: fragment of a bigger structure
Location inside paper: Fig. 2, compound 1
Aglycon: oligosaccharide in the mucins of T. cruzi
Trivial name: α-gal epitope
Contained glycoepitopes: IEDB_115013,IEDB_130645,IEDB_130646,IEDB_130649,IEDB_135813,IEDB_135815,IEDB_136044,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_140108,IEDB_140122,IEDB_141496,IEDB_141794,IEDB_141807,IEDB_146694,IEDB_149558,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_418918,IEDB_689191,IEDB_918314,SB_165,SB_166,SB_187,SB_195,SB_30,SB_40,SB_7,SB_87,SB_88
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error