Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 10230038Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: awzam
ichf.edu.pl
Institutions: I.I. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117871 Moscow, Russian Federation, N.D. Zelinsky Institute of Organic Chemistry, Leninsky pr. 47, 117913 Moscow, Russian Federation, Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44, PL-01-224 Warsaw, Poland, Division of Medical and Biochemical Microbiology, Research Center Borstel, Center for Medicine and Biological Sciences, Borstel, Germany, M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117871 Moscow, Russian Federation
Synthesis of the title trisaccharide was accomplished by sugar chain extension starting from the non-reducing terminus: coupling of GlcpNAc with LD-Hepp, then adding Glcp-OAll. An alternative route started from the reducing end: coupling of LD-Hepp with Glcp-OAll, then addition of GlcpNAc. In the synthesis of the title disaccharide a modification of the first approach was employed. The allyl glycosides were coupled with cysteamine, activated with thiophosgene and conjugated to bovine serum albumin (BSA). The neoglycoconjugates obtained were used in immunochemical studies of monoclonal and polyclonal antibodies directed against Escherichia coli K-12 lipopolysaccharide.
Escherichia coli, polysaccharides, Sugar chain extension
Structure type: oligomer
Location inside paper: p. 86, compound 2
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_2189047
Methods: NMR, LSI-MS, chromatography
Biological activity: serological data
Synthetic data: chemical
Related record ID(s): 40
NCBI Taxonomy refs (TaxIDs): 83333Reference(s) to other database(s): GlycomeDB:
25070
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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