Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
The structure was elucidated in this paperNCBI PubMed ID: 196639Publication DOI: 10.1021/bi00635a028Journal NLM ID: 0370623Publisher: American Chemical Society
A polysaccharide, antigenically related to group C meningococcus, has been isolated from Escherichia coli strain Bos-12 (016; K92; NM). Like groups B and C meningococcal polysaccharide, the Bos-12 antigen is a pure polymer of sialic acid. 13C NMR studies on the meningococcal group B and C polysaccharides have indicated that the former consists of sialic acid units linked 2→8-α, whereas the latter contains the sialic acid residues linked 2→9-α (Bhattacharjee, A.K., Jennings, H.J., Kenny, C.P., Martin, A., and Smith, I.C.P. (1975), J. Biol. Chem. 250, 1926). Comparison of natural abundance 13C NMR spectra of the Bos-12 polysaccharide with group B and C meningococcal polysaccharides established that Bos-12 was either (a) an equimolar mixture of 2→8-α linked sialic acid homopolymers or (b) a 2→8-α / 2→9-α heteropolymer. These possibilities were distinguished in the following manner. The fact that Bos-12 polysaccharide precipitated with anti-group C serum but not with anti-group B serum would seem to exclude a. Further, chemical studies (periodate oxidation followed by tritiated NaBH4 reduction) gave saccharides with a radioactive-labeling pattern expected for alternating 2→8-α / 2→9-α sialic acid linkages. Bos-12 is thus an 2→8-α / 2→9-α heteropolymer.
Structure type: polymer chemical repeating unit
Trivial name: colominic acid, polysialic acid, α-2,8/2,9-linked polysialic acid
Compound class: CPS, K-antigen
Contained glycoepitopes: IEDB_136794,IEDB_146100,IEDB_149174,IEDB_150937,IEDB_153199,SB_170,SB_171,SB_172,SB_35,SB_42,SB_84
Methods: 13C NMR
Related record ID(s): 3427, 8310, 101038, 126508
NCBI Taxonomy refs (TaxIDs): 562Reference(s) to other database(s): GTC:G85948DP, GlycomeDB:
26537
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error