Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Bacillus anthracis [ICD11:
XN94F 
]
NCBI PubMed ID: 15922317Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: kpn
helix.nih.gov
Institutions: NIDDK, LMC, National Institutes of Health, Bethesda, MD 20892-0815, USA
The key step in the first chemical synthesis of anthrose (16) and its methyl α- (6) and β-glycoside (22) was inversion of configuration at C-2 in triflates 10, 2, and 18, respectively, obtained from the common intermediate, methyl 4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside (1). To prepare methyl α-anthroside (6), methylation at O-2 of the gluco product 3, obtained from 2, was followed by hydrogenation/hydrogenolysis of the formed 2-methyl ether 4, to simultaneously remove the protecting benzyl group and reduce the azido function. Subsequent N-acylation of the formed amine 5 with 3-hydroxy-3-methylbutyric acid gave the target methyl α-glycoside 6. Synthesis of methyl β-anthroside (22) comprised the same sequence of reactions, starting from the known methyl 4-azido-3-O-benzyl-4,6-dideoxy-β-D-mannopyranoside (17), which was prepared from 1. In the synthesis of anthrose (16), 1-thio-β-glucoside 11, obtained from 1 through 10, was methylated at O-2, and the azido function in the resulting benzylated 1-thioglycoside 12 was selectively reduced to give amine 13. After N-acylation with 3-hydroxy-3-methylbutyric acid, 1-thioglycoside 14 was hydrolyzed to give the corresponding reducing sugar, aldol 15, which was debenzylated to afford anthrose.
perosamine, methyl α-anthroside, methyl β-anthroside, thioglycoside hydrolysis
Structure type: monomer
Location inside paper: p.1593, Scheme 2, compound 16
Trivial name: anthrose
Contained glycoepitopes: IEDB_146676
Methods: chemical methods
Synthetic data: chemical
Comments, role: terminal tetrasaccharide of the surface glycoprotein
Related record ID(s): 10613, 10768, 10769
NCBI Taxonomy refs (TaxIDs): 1392
Show glycosyltransferases
There is only one chemically distinct structure:
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